Results 41 to 50 of about 3,356,214 (292)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Reliability assessment for Modular Multilevel Converters using Monte Carlo Simulations

International Journal of Electrical Power & Energy Systems
Modular Multilevel Converters (MMCs) offer significant advantages in the medium to high-voltage settings. The modular architecture of MMCs allows for redundant submodules (SMs) to improve overall reliability.
Miad Ahmadi, Aditya Shekhar, Pavol Bauer
doaj   +1 more source

Security Analysis of Dynamic Heterogeneous Redundant System [PDF]

Jisuanji gongcheng, 2018
The main causes of threats to cyberspace security are vulnerabilities and backdoor problems.In order to solve the threats based on unknown vulnerabilities,backdoor or virus Trojans in cyberspace,a probabilistic mathematical model is established for the ...
WANG Wei,ZENG Junjie,LI Guangsong
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Mixed Redundancy Strategy for Modular Multilevel Converters in High-Power Applications

IEEE Open Journal of the Industrial Electronics Society
Modular multilevel converters are favorable for efficiently operating high-power usages. The required number of components significantly increases when higher modularity is introduced for the given voltage level, thus reducing the system's ...
Miad Ahmadi, Aditya Shekhar, Pavol Bauer
doaj   +1 more source

Distributed power generation and power supply reliability improvement [PDF]

E3S Web of Conferences, 2020
The appearance of distributed generation in the power supply systems of industrial enterprises leads to the emergence of requirements for networks to increase their redundancy functions.
Byk Felix, Kakosha Yuri, Myshkina Lyudmila   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Fault Tolerant Scheduling Heuristics for Distributed Real Time Embedded Systems

Cybernetics and Information Technologies, 2018
In this paper, fault tolerant task scheduling algorithms are proposed for mapping task graphs to heterogeneous processing nodes. These scheduling heuristics that we propose are redundancy-based software to tolerate hardware faults.
Malika Bachir, Kalla Hamoudi
doaj   +1 more source

Redundant role for Zap70 in B cell development and activation [PDF]

European Journal of Immunology, 2008
AbstractExpression of the Syk family tyrosine kinase Zap70 is strongly correlated with poor clinical outcome in chronic lymphocytic leukemia, the most common human leukemia characterized by B cell accumulation. The expression of Zap70 may reflect the specific cell of origin of the tumor or may contribute to pathology.
Farnaz, Fallah-Arani, Edina, Schweighoffer, Lesley, Vanes, Victor L J, Tybulewicz   +3 more
openaire   +2 more sources