Results 51 to 60 of about 3,356,214 (292)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Active redundancy allocation in systems [PDF]

, 2002
An effective way of improving the reliability of a system is the allocation of active redundancy. Let $X_{1}$, $X_{2}$ be independent lifetimes of the components $C_{1}$ and $C_{2}$, respectively, which form a series system.
Romera Ayllón, María Rosario, Valdés, José, Zequeira, R.   +2 more
core   +2 more sources

Modelling of High Redundancy Actuation Utilising Multiple Moving Coil Actuators [PDF]

, 2008
This paper presents the modelling of a moving coil actuator for use as an element in a High Redundancy Actuator (HRA). A single element model is derived from first principles and verified using experimental data.
Thomas Steffen (1252947), Dixon, R., Pearson, John, T. Steffen, J. Davies, R. Dixon, Roger Goodall (1250520), Goodall, R. M., Dixon, Roger; id_orcid, Dixon, Roger, Jessica Davies (3927101), Roger Dixon (1259193), Argyrios C. Zolotas (7122554), J. Pearson, R.M. Goodall, A.C. Zolotas, Steffen, Thomas, John T. Pearson (7121711), Goodall, Roger M., Davies, Jessica, Zolotas, Argyrios   +20 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Hybrid fault tolerant control for air–fuel ratio control of internal combustion gasoline engine using Kalman filters with advanced redundancy

Measurement + Control, 2019
In this paper, a hybrid fault tolerant control system is proposed for air–fuel ratio control of internal combustion gasoline engines based on Kalman filters and triple modular redundancy.
Arslan Ahmed Amin, Khalid Mahmood-ul-Hasan   +1 more
doaj   +1 more source

Foveated active tracking with redundant 2D motion parameters [PDF]

Robotics and Autonomous Systems, 2002
Abstract This work presents a real-time active vision tracking system based on log-polar image motion estimation with 2D geometric deformation models. We present a very efficient parametric motion estimation method, where most computation can be done offline.
Alexandre Bernardino, José Santos-Victor, Giulio Sandini   +2 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Redundant and Cryptic Enhancer Activities of the Drosophila   yellow Gene [PDF]

Genetics, 2018
Abstract Evolutionary changes in enhancers, which control gene expression, often contribute to phenotypic evolution. Here, Kalay et al. examine how enhancer activities are encoded within non-coding sequences surrounding the pigmentation gene yellow from three Drosophila species...
Kalay, Gizem, Lachowiec, Jennifer, Rosas, Ulises, Dome, Mackenzie R., Wittkopp, Patricia   +4 more
openaire   +2 more sources