Results 121 to 130 of about 1,351,620 (240)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Correlation between active regions' spectra at high radio frequencies and solar flare occurrences. [PDF]

Sci Rep
Mulas S, Pellizzoni A, Marongiu M, Marcucci A, Righini S, Iacolina MN, Egron E, Murtas G, Bachetti M, Berrilli F, Cabras A, Caocci R, Deiana GL, Guglielmino SL, Haggerty C, Ladu A, Loru S, Maccaferri A, Marongiu P, Melis A, Navarrini A, Orfei A, Ortu P, Pili M, Pisanu T, Pupillo G, Saba A, Schirru L, Serra G, Tiburzi C, Valente G, Zanichelli A, Zucca P, Messerotti M.   +33 more
europepmc   +1 more source

A low upper limit on the subsurface rise speed of solar active regions. [PDF]

Sci Adv, 2016
Birch AC, Schunker H, Braun DC, Cameron R, Gizon L, Löptien B, Rempel M.   +6 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Analysis of the Influence of Clear-Sky Fluxes on the Cloud-Type Mean Cloud Radiative Effects in the Tropical Convectively Active Regions With CERES Satellite Data. [PDF]

J Geophys Res Atmos
Xu KM, Sun M, Zhou Y.
europepmc   +1 more source

Transcriptionally active regions are the preferred targets for chromosomal HPV integration in cervical carcinogenesis. [PDF]

PLoS One, 2015
Christiansen IK, Sandve GK, Schmitz M, Dürst M, Hovig E.   +4 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Using Long-Term Satellite Observations to Identify Sensitive Regimes and Active Regions of Aerosol Indirect Effects for Liquid Clouds Over Global Oceans. [PDF]

J Geophys Res Atmos, 2018
Zhao X, Liu Y, Yu F, Heidinger AK.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Modelling nanoflares in active regions and implications for coronal heating mechanisms. [PDF]

Philos Trans A Math Phys Eng Sci, 2015
Cargill PJ, Warren HP, Bradshaw SJ.
europepmc   +1 more source