Results 61 to 70 of about 1,351,620 (240)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Self-reported domain-specific and accelerometer-based physical activity and sedentary behaviour in relation to psychological distress among an urban Asian population

International Journal of Behavioral Nutrition and Physical Activity, 2018
Background The interpretation of previous studies on the association of physical activity and sedentary behaviour with psychological health is limited by the use of mostly self-reported physical activity and sedentary behaviour, and a focus on Western ...
A. H. Y. Chu, R. M. van Dam, S. J. H. Biddle, C. S. Tan, D. Koh, F. Müller-Riemenschneider   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Not Only Systemin: Prosystemin Harbors Other Active Regions Able to Protect Tomato Plants. [PDF]

Front Plant Sci, 2022
Molisso D, Coppola M, Buonanno M, Di Lelio I, Aprile AM, Langella E, Rigano MM, Francesca S, Chiaiese P, Palmieri G, Tatè R, Sinno M, Barra E, Becchimanzi A, Monti SM, Pennacchio F, Rao R.   +16 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Image patch analysis of sunspots and active regions

Journal of Space Weather and Space Climate, 2016
Context. The flare productivity of an active region is observed to be related to its spatial complexity. Mount Wilson or McIntosh sunspot classifications measure such complexity but in a categorical way, and may therefore not use all the information ...
Moon Kevin R., Li Jimmy J., Delouille Véronique, De Visscher Ruben, Watson Fraser, Hero Alfred O.   +5 more
doaj   +2 more sources

Comparing Solar Structure Detection Methods in SDO/AIA Observations and the Application to Raw Uncalibrated Data

Journal of Geophysical Research: Machine Learning and Computation
Recent advances in solar physics increasingly rely on automated identification of coronal structures using machine learning. Yet most studies emphasize scientific performance without evaluating feasibility for onboard deployment to prioritize downlink ...
P. Gonidakis, F. Carella, E. Dineva, H‐J. Jeong, P. Antunes, A. Podobas, S. Raptis, V. Toy‐Edens, M. Jin, S. Poedts, J. Magdalenic, G. Miloshevich   +11 more
doaj   +1 more source

Direct evidence that twisted flux tube emergence creates solar active regions. [PDF]

Nat Commun, 2021
MacTaggart D, Prior C, Raphaldini B, Romano P, Guglielmino SL.   +4 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source