Results 71 to 80 of about 6,770,206 (281)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Comparing Solar Structure Detection Methods in SDO/AIA Observations and the Application to Raw Uncalibrated Data

Journal of Geophysical Research: Machine Learning and Computation
Recent advances in solar physics increasingly rely on automated identification of coronal structures using machine learning. Yet most studies emphasize scientific performance without evaluating feasibility for onboard deployment to prioritize downlink ...
P. Gonidakis, F. Carella, E. Dineva, H‐J. Jeong, P. Antunes, A. Podobas, S. Raptis, V. Toy‐Edens, M. Jin, S. Poedts, J. Magdalenic, G. Miloshevich   +11 more
doaj   +1 more source

Self-reported domain-specific and accelerometer-based physical activity and sedentary behaviour in relation to psychological distress among an urban Asian population

International Journal of Behavioral Nutrition and Physical Activity, 2018
Background The interpretation of previous studies on the association of physical activity and sedentary behaviour with psychological health is limited by the use of mostly self-reported physical activity and sedentary behaviour, and a focus on Western ...
A. H. Y. Chu, R. M. van Dam, S. J. H. Biddle, C. S. Tan, D. Koh, F. Müller-Riemenschneider   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Not Only Systemin: Prosystemin Harbors Other Active Regions Able to Protect Tomato Plants. [PDF]

Front Plant Sci, 2022
Molisso D, Coppola M, Buonanno M, Di Lelio I, Aprile AM, Langella E, Rigano MM, Francesca S, Chiaiese P, Palmieri G, Tatè R, Sinno M, Barra E, Becchimanzi A, Monti SM, Pennacchio F, Rao R.   +16 more
europepmc   +1 more source

Sewerage and sewage disposal in cold regions

, 2020
COLD REGIONS SCIENCE AND ENGINEERING Mo n o g ra p h 111 - C 5 b 111-C5 b "sewerage and sewage disposal IN COLD REGIONS^ .3"Amos J. Al ter iOctp*be-r 1 9 6 9/, 2. CORPS OF ENGINEERS, U.S.
Cold Regions Research and Engineering Laboratory (U.S.)
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Direct evidence that twisted flux tube emergence creates solar active regions. [PDF]

Nat Commun, 2021
MacTaggart D, Prior C, Raphaldini B, Romano P, Guglielmino SL.   +4 more
europepmc   +1 more source