Results 81 to 90 of about 828,248 (268)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Promoting Discussions in Safety Review Activity
Chemical Engineering Transactions, 2013 Discussion from diversified viewpoints is very important for process safety review. Therefore to promote discussion is essential for improvement of process safety. Mitsubishi Chemical Corporation has been working to improve process safety by performing safety review (SR) activities.
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Active safety surveillance of rabies monoclonal antibody and rabies vaccine in patients with category III potential rabies exposure. [PDF]
Lancet Reg Health Southeast Asia, 2023 Kang G +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Improving Knowledge of Active Safety and QI Projects Amongst Practitioners in a Pediatric ICU. [PDF]
Pediatr Qual Saf, 2022 Flaherty BF +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Stochastic prediction model for obstacle avoidance route of pedestrian
Nihon Kikai Gakkai ronbunshu, 2017 This paper describes a modeling method for predicting a walking route of a pedestrian in a stochastic manner. We consider one of the most typical situations where a pedestrian walks along to a sidewalk, and then some obstacle exists in front of the ...
Hiroyuki TAKANASHI +5 more
doaj +1 more source
Active Safety Surveillance of Four Types of COVID-19 Vaccines: A National Study from Jordan. [PDF]
Clin Drug Investig, 2022 Abdel-Qader DH +21 more
europepmc +1 more source