Results 71 to 80 of about 828,248 (268)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ACTIVE SAFETY IN THE SYSTEM OF MOTOR-TRANSPORT SAFETY

Automobile Transport, 2016
The article considers the impact of active safety on motor-transport safety and on road traffic safety with the purpose of RTA preclusion. The matter of active safety in the system of motor-transport safety is furnished, the main trends in improving traffic safety are determined. While considering the problems of motor transport safety and the problems
openaire   +4 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Determining Tyre Adhesion Characteristics Based on the Road Tests of Automobiles

Sensors
The motion of automobiles significantly depends on the conditions of interaction between a tyre and a road surface. One of the most frequently used ways of presenting the conditions of cooperation between a tyre and a road surface is a characteristic ...
Andrzej Reński, Mateusz Brukalski, Hubert Sar, Michał Abramowski, Piotr Fundowicz, Krzysztof Rokicki   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Minimum Initial Marking Estimation in Labeled Petri Nets With Unobservable Transitions

IEEE Access, 2019
In the literature, researchers have been studying the minimum initial marking (MIM) estimation problem in the labeled Petri nets with observable transitions. This paper extends the results to labeled Petri nets with unobservable transitions (with certain
Keyu Ruan, Lingxi Li, Weimin Wu
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

ON THE QUESTION OF THE SAFETY OF A 4-ALKYL-SUBSTITUTED COMPOUND WITH ANTI-TUMOUR ACTION

Кубанский научный медицинский вестник, 2019
The aim was to investigate the acute toxicity of the AX-554 compound following its intragastric administration, as well as to determine the effective cytotoxic concentration and dose of this preparation.Materials and methods.
Marina O. Dudina, Ekaterina V. Blinova, Inessa Ya. Moiseeva, Elena A. Samyshina, Irina R. Suslova, Dmitrii S. Blinov   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source