Results 61 to 70 of about 6,205,927 (307)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Development characteristics and prediction model of the water-conducting fractured zone in typical mining-induced structural overburden in the mountainous areas of Southwestern China

Frontiers in Built Environment
IntroductionIn mining areas of the mountainous regions of Southwestern China, the overlying strata above goafs are mostly thick bedrock with well-developed structural planes. With large-scale exploitation of mineral resources, extensive water- conducting
Jun Li, Jun Li, Jiawei Wan, Jiawei Wan, Xiang Li, Xiang Li, Xingxing Du, Xingxing Du, Haoyuan Gao, Haoyuan Gao, Bin Li, Bin Li   +11 more
doaj   +1 more source

A review of safety test methods for new car assessment program in Southeast Asian countries

Open Engineering, 2023
Vehicles with advanced active safety technology can decrease the significant traffic accidents that can lead to death. This active safety frontier falls under primary safety in the European New Car Assessment Program (Euro NCAP) 2025 Roadmap, which has ...
Halimi Siti Nur Atiqah, Rasmana Susijanto Tri, Adiputra Dimas, Yahya Wira Jazair, Rahman Mohd Azizi Abdul, Ariff Mohd Hatta Mohammed, Husain Nurulakmar Abu, Kassim Khairil Anwar Abu   +7 more
doaj   +1 more source

Safety of Transport Activities

Central Ukrainian Scientific Bulletin. Technical Sciences
In the national dimension, transport safety, as a comprehensive characteristic, defines the state of protection of transport infrastructure facilities. This ensures security and interests in the field of transport activities, resilience of transport operations, and the ability to prevent harm to human health and life, property damage, and environmental
Ihor Khitrov, Svetlana Kozak
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The effect of a new 3-hydroxypyridine derivative LHT-2-20 on free radical oxidation in experimental periodontitis

Бюллетень сибирской медицины
Aim. To study the effect of a new complex compound LHT-2-20 (2-ethyl-6-methyl-3-hydroxypyridine-2-(3benzoyl phenyl)-propanoate) on free radical oxidation in experimental periodontitis.Materials and methods.
G. V. Poryadin, A. N. Zakhvatov, V. V. Yasnetsov, S. Ya. Skachilova, D. A. Khaydar, T. V. Tarasova, I. A. Zakharkin, A. Yu. Parshina, E. A. Simakina   +8 more
doaj   +1 more source

Some Aspects of Vehicle Active Safety [PDF]

International Journal of Occupational Safety and Ergonomics, 1995
Three selected aspects of vehicle active safety are presented in this article: (a) modeling the driver and the driver-vehicle environment system, (b) the dynamic aspects of vehicle rollover, and (c) an analysis of the process of passing. Sample solutions and results show the need for further research in the field of vehicle safety in order to lower the
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source