Results 91 to 100 of about 190,143 (303)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Can ChatGPT Ease Digital Fatigue? Short-Cycle Content Curation for University Instructors

Education Sciences
Digital fatigue is pervasive among university instructors, yet rigorous evidence on whether generative AI improves well-being is scarce. We conducted an eight-week staggered multiple-baseline AB–AB reversal with eight lecturers at a private Peruvian ...
Verónica Tomasa Cajas Bravo, Lupe Marilu Huanca Rojas, Andrés Arias Lizares, Juan Cielo Ramírez Cajamarca, Fernando Vasquez Perdomo, Miguel Angel De la Cruz Cruz, Hilario Romero Girón, Ana María Guerrero Millones, Roberto Carlos Dávila-Morán   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Factors Influence Reading From Screen of Arabic Textbook for Learning by Children Aged 9 to 13

The problem with e-texts are related to the way texts are displayed on a screen, with multiple and different aspects that affect legibility, making readers prefer to read a paper format rather than e-resources.
Abubaker, Azza
core   +1 more source

Global profiling of α-glucosidase inhibitors from Citri Reticulatae Pericarpium based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS method.

PLoS ONE
As a medicinal and edible herb, Citri Reticulatae Pericarpium has multiple biological activities. The latest modern pharmacological researches have found that Citri Reticulatae Pericarpium has the effect of lowering blood sugar, and its extract can ...
Hongping Wang, Qiong Yin, Zhaozhou Lin, Quantao Ma, Zhaohua Zhang, Jun Jia   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An improved thick-film piezoelectric material by powder blending and enhanced processing parameters

, 2005
This paper details improvements of the d33 coefficient for thick-film lead zirconate titanate (PZT) layers. In particular, the effect of blending ball and attritor milled powders has been investigated.
White, N.M., Beeby, S.P., Torah, R.
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Investigating the anti-cancer activity of novel osmium-arene compounds using CRISPR screening technology [PDF]

Acquired resistance to chemotherapeutic agents is a common problem in the treatment of cancer. Whilst combination therapy of cisplatin and taxol is the first line treatment for ovarian cancer, around 15% of patients do not respond to this regimen and 80% of those that do relapse within 18-24 months with cisplatin-resistant disease.
openaire   +1 more source