Results 51 to 60 of about 190,143 (303)

Fabrication of paper-based enzyme immobilized microarray by 3D-printing technique for screening α-glucosidase inhibitors in mulberry leaves and lotus leaves

Chinese Medicine, 2019
Background The discovery of bioactive compounds in traditional Chinese medicine (TCM) has become an important field in TCM modernization. Ligand fishing is a suitable method for discovery of bioactive compounds in complex mixtures such as TCM with high ...
Shangxin Guo, Xiaotong Lin, Yi Wang, Xingchu Gong   +3 more
doaj   +1 more source

High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT Tuberculosis remains a major health problem due to the emergence of drug-resistant strains of Mycobacterium tuberculosis . Some models have provided valuable information about drug resistance and efficacy; however, the translation of these results into effective human treatments has mostly proven ...
Silva-Miranda, Mayra, Ekaza, Euloge, Breiman, Adrien, Asehnoune, Karim, Barros-Aguirre, David, Pethe, Kevin, Ewann, Fanny, Brodin, Priscille, Ballell-Pages, Lluís, Altare, Frédéric   +9 more
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Field Switching in an Enclosure with an Active FSS Screen

, 2001
The measured performance of an active frequency selective surface (AFSS) applied to an internal wall of a building to provide switchable screening is summarised. The AFSS has also been used to screen one face of a cubic enclosure.
Parker, Edward A., Cahill, B.M.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The rise of electrochromics through dynamic QR codes and grayscale images in screen printed passive matrix addressed displays

Scientific Reports, 2022
Electronic matrix addressed displays capable of presenting arbitrary grayscale images typically require complex device architectures including switching components to provide unique pixel addressability.
Peter Andersson Ersman, Kathrin Freitag, Jun Kawahara, Jessica Åhlin   +3 more
doaj   +1 more source

A Rapid Screening Analysis of Antioxidant Compounds in Native Australian Food Plants Using Multiplexed Detection with Active Flow Technology Columns [PDF]

Molecules, 2016
Conventional techniques for identifying antioxidant and phenolic compounds in native Australian food plants are laborious and time-consuming. Here, we present a multiplexed detection technique that reduces analysis time without compromising separation performance. This technique is achieved using Active Flow Technology-Parallel Segmented Flow (AFT-PSF)
Rupesinghe, Emmanuel, Jones, Andrew, Shalliker, Ross, Pravadali-Cekic, Sercan   +3 more
openaire   +5 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Affinity Ultrafiltration Mass Spectrometry for Screening Active Ingredients in Traditional Chinese Medicine: A Review of the Past Decade (2014–2024)

Molecules
Discovering targets in natural products is a critical and challenging task in new drug development. Rapid and efficient screening of active ingredients from complex systems like traditional Chinese medicine (TCM) is now crucial in drug research. Affinity
Yuqi He, Xinyan Zhao, Muze Yu, Di Yang, Lian Chen, Ce Tang, Yi Zhang   +6 more
doaj   +1 more source

APLIKASI TIGA DIMENSI VIRTUAL DENGAN MENGGUNAKAN 5DT DATA GLOVE 5 ULTRA

JUTI: Jurnal Ilmiah Teknologi Informasi, 2008
One of active area in information technology research is development of virtual reality (VR). It is a technology which can simulate real world activities in a virtual world.
Yulia Yulia, Rudy Adipranata, Wiradinata Eddy   +2 more
doaj   +1 more source