Results 61 to 70 of about 190,143 (303)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dual Polarized Reconfigurable Frequency Selective Surfaces [PDF]

, 2013
Novel band-stop active frequency selective surfaces (FSS) capable of modifying their response for different polarizations are proposed. Geometries based on full rings, and split rings are employed.
Sanz-Izquierdo, B., Parker, E.A.
core   +1 more source

New technologies and leisure activities for young people in Dakar: small screens connected to the conflicts between parents and teenagers in pikine

International Journal of Engineering & Technology, 2022
The almost irreversible and encouraged link between connectable computer terminals and playful juvenile occupation raises the issue of parental education in the family environment. The latter is characterized by its narrowness and the almost daily absence of parents, hence the question of the uncontrolled use of tablets and smartphones connected by ...
Dr. Souleymane DIALLO, Dr. Ousmane BA
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Encoded Library Technology Screening of Hepatitis C Virus NS4B Yields a Small-Molecule Compound Series with In Vitro Replicon Activity [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT To identify novel antivirals to the hepatitis C virus (HCV) NS4B protein, we utilized encoded library technology (ELT), which enables purified proteins not amenable to standard biochemical screening methods to be tested against large combinatorial libraries in a short period of time.
Christopher, Arico-Muendel, Zhengrong, Zhu, Hamilton, Dickson, Derek, Parks, Jesse, Keicher, Jianghe, Deng, Leah, Aquilani, Frank, Coppo, Todd, Graybill, Kenneth, Lind, Andrew, Peat, Michael, Thomson   +11 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Feasibility trial evaluation of a physical activity and screen-viewing course for parents of 6 to 8 year-old children : Teamplay [PDF]

, 2013
Background: Many children spend too much time screen-viewing (watching TV, surfing the internet and playing video games) and do not meet physical activity (PA) guidelines. Parents are important influences on children’s PA and screen-viewing (SV).
Simon J Sebire, Russell Jago, Bentley, Georgina F., Patricia J Lucas, Goodred, Joanna K., Sebire, Simon J, Turner, Katrina M., Kenneth R Fox, Stewart-Brown, Sarah L, Jago, Russell, Sebire, Simon J., Fox, Kenneth R, Katrina M Turner, Sarah Stewart-Brown, Fox, Kenneth R., Bentley, Georgina F, Joanna K Goodred, Georgina F Bentley, Lucas, Patricia J., Lucas, Patricia J, Goodred, Joanna K, Stewart-Brown, Sarah L., Turner, Katrina M   +22 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Impact of Gadget Use on the Decrease in Students' Physical Activity in Everyday Life

Active: journal of physical education, sport, health and recreation
Digital technology advancement has led to increased gadget usage among elementary school students but their extended screen time and high screen exposure risks transforming their daily activities from active play to sedentary behavior.
Suci Nurhafifah, Aam Ali Rahman, Dinar Dinangsit   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source