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Superfamily active site templates
Proteins: Structure, Function, and Bioinformatics, 2004AbstractWe show that three‐dimensional signatures consisting of only a few functionally important residues can be diagnostic of membership in superfamilies of enzymes. Using the enolase superfamily as a model system, we demonstrate that such a signature, or template, can identify superfamily members in structural databases with high sensitivity and ...
Elaine C, Meng +2 more
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Modulating caspase activity: beyond the active site
Current Opinion in Structural Biology, 2013Caspases are a family of aspartate-specific cysteine proteases that regulate cellular homeostasis through the mediation of apoptosis and inflammation. Despite keen interest in caspases as therapeutic targets for cancer, inflammatory, and neurodegenerative diseases, no active-site directed small molecule has yet succeeded in navigating human clinical ...
Jeremy, Murray, Adam R, Renslo
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Active-site probes of flavoproteins
Biochemical Society Transactions, 1980Flavins are very versatile coenzymes, functioning with considerable efficiency in a wide variety of enzymic reactions involving either two-electron or one-electron transfers, with both functions often catalysed by the same enzyme. They are responsible for catalysing the dehydrogenation of many different types of compounds, including dithiols, reduced ...
V, Massey, P, Hemmerich
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Indirect active-site titration of plasminogen activators
Analytical Biochemistry, 1988A method for the determination of the molar concentration of active tissue plasminogen activator (TPA) and urokinase (UK) has been developed. The method employs the principle of back-titration of a calibrated trypsin standard with a calibrated standard solution of a chloromethyl ketone inhibitor reactive with both trypsin and activator.
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1985
Monoclonal antibodies (MAbs) have provided powerful new tools for analysis of enzyme function. MAbs directed at specific subsites of the enzyme active site allow analysis of catalysis at a new level of resolution even for relatively simple, monomeric enzymes.
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Monoclonal antibodies (MAbs) have provided powerful new tools for analysis of enzyme function. MAbs directed at specific subsites of the enzyme active site allow analysis of catalysis at a new level of resolution even for relatively simple, monomeric enzymes.
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A‐Site Management Prompts the Dynamic Reconstructed Active Phase of Perovskite Oxide OER Catalysts
Advanced Energy Materials, 2021Yu Sun, Qingliang Liao, Zhuo Kang
exaly
The concept of active site in heterogeneous catalysis
Nature Reviews Chemistry, 2022Charlotte Vogt, Bert M Weckhuysen
exaly
Covalent Labeling of Active Sites
1967Publisher Summary This chapter deals with the covalent labeling of active sites. The active sites are three dimensional structures specially adapted to their specific ligands. This chapter illustrates that three types of protein are involved in the direct catalytic interaction with the specific substrate.
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