Results 361 to 370 of about 11,841,496 (406)

The Progress and Outlook of Metal Single-Atom-Site Catalysis.

Journal of the American Chemical Society, 2022
Single-atom-site catalysts (SASCs) featuring maximized atom utilization and isolated active sites have progressed tremendously in recent years as a highly prosperous branch of catalysis research. Varieties of SASCs have been developed that show excellent
Xiao Liang, Ninghua Fu, Shuangchao Yao, Zhi Li, Yadong Li   +4 more
semanticscholar   +1 more source

The active site of Rubisco

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1986
Previous affinity-labelling studies and comparative sequence analyses have identified two different lysine residues at the active site of ribulose bisphosphate carboxylaseoxygenase and have suggested that they are essential to function. The essential lysine residues occupy positions 166 and 329 in the Rhodospirillum rubrum
C.D. Stringer, Fred C. Hartman, Sylvia Milanez, Eva H. Lee   +3 more
openaire   +2 more sources

Isolated metal active site concentration and stability control catalytic CO2 reduction selectivity.

Journal of the American Chemical Society, 2015
CO2 reduction by H2 on heterogeneous catalysts is an important class of reactions that has been studied for decades. However, atomic scale details of structure-function relationships are still poorly understood.
John C. Matsubu, Vanessa N Yang, P. Christopher   +2 more
semanticscholar   +1 more source

Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.

ACS Chemical Biology, 2015
This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes. Specific tyrosine residues in the active site of the mRNA-decapping scavenger enzyme DcpS were modified using reactive ...
Erik C. Hett, Hua Xu, K. Geoghegan, A. Gopalsamy, Robert E. Kyne, C. Menard, A. Narayanan, Mihir D. Parikh, Shenping Liu, Lee R. Roberts, R. Robinson, M. A. Tones, L. Jones   +12 more
semanticscholar   +1 more source

Out of the active site binding pocket for carbonic anhydrase inhibitors.

Chemical Communications, 2015
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this ...
Katia D'Ambrosio, S. Carradori, S. Monti, Martina Buonanno, D. Secci, D. Vullo, C. Supuran, G. De Simone   +7 more
semanticscholar   +1 more source

Molecular dynamics explorations of active site structure in designed and evolved enzymes.

Accounts of Chemical Research, 2015
This Account describes the use of molecular dynamics (MD) simulations to reveal how mutations alter the structure and organization of enzyme active sites. As proposed by Pauling about 70 years ago and elaborated by many others since then, biocatalysis is
Sílvia Osuna, Gonzalo Jiménez‐Osés, Elizabeth L Noey, K. Houk   +3 more
semanticscholar   +1 more source

Perturbations to the Active Site of Phosphotriesterase

Biochemistry, 1997
Phosphotriesterase catalyzes the hydrolysis of organophosphate nerve agents. Four amino acid residues, located within the active site pocket, were mutated in an effort to ascertain the roles that these groups play in the structure and function of this enzyme.
Frank M. Raushel, Jane M. Kuo, Myeong Yun Chae   +2 more
openaire   +3 more sources

The concept of active site in heterogeneous catalysis

Nature Reviews Chemistry, 2022
C. Vogt, B. Weckhuysen
semanticscholar   +1 more source

Plasticity of enzyme active sites

Trends in Biochemical Sciences, 2002
The expectation is that any similarity in reaction chemistry shared by enzyme homologues is mediated by common functional groups conserved through evolution. However, detailed enzyme studies have revealed the flexibility of many active sites, in that different functional groups, unconserved with respect to position in the primary sequence, mediate the ...
Janet M. Thornton, Annabel E. Todd, Christine A. Orengo   +2 more
openaire   +3 more sources

Phenylenediamine-based FeN(x)/C catalyst with high activity for oxygen reduction in acid medium and its active-site probing.

Journal of the American Chemical Society, 2014
High-temperature pyrolyzed FeN(x)/C catalyst is one of the most promising nonprecious metal electrocatalysts for oxygen reduction reaction (ORR). However, it suffers from two challenging problems: insufficient ORR activity and unclear active site ...
Qiang Wang, Zhiyou Zhou, Yu-Jiao Lai, Y. You, Jian-Guo Liu, Xia-Ling Wu, Ephrem Terefe, Chi Chen, Lin Song, M. Rauf, Na Tian, Shigang Sun   +11 more
semanticscholar   +1 more source