Results 81 to 90 of about 1,610,463 (321)
Molecules, 2020 Previously, a hypothetical protein (HP) termed Bleg1_2437 (currently named Bleg1_2478) from Bacillus lehensis G1 was discovered to be an evolutionary divergent B3 subclass metallo-β-lactamase (MBL).
Gayathri Selvaraju +3 more
doaj +1 more source
Active-Site Motion and Pattern Formation in Self-Organised Interface Depinning [PDF]
arXiv, 1996 We study a dynamically generated pattern in height gradients, centered around the active growth site, in the steady state of a self-organised interface depinning model. The pattern has a power-law tail and depends on interface slope. An approximate integral equation relates the profile to local interface readjustments and long-ranged jumps of the ...
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Fluctuations of Electric Fields in the Active Site of the Enzyme Ketosteroid Isomerase [PDF]
arXiv, 2019 We report the effect of conformational dynamics on the fluctuations of electric fields in the active site of the enzyme Ketosteroid Isomerase (KSI). While KSI is considered rigid with little conformational variation to support different stages of the catalytic cycle, we show that KSI utilizes cooperative side chain motions of the entire protein ...
arxiv
Assessing the Precision and Recall of msTALI as Applied to an Active-Site Study on Fold Families [PDF]
arXiv, 2020 Proteins execute various activities required by biological cells. Further, they structurally support and pro-mote important biochemical reactions which functionally are sparked by active-sites. Active-sites are regions where reac-tions and binding events take place directly; they foster pro-tein purpose.
arxiv
An exactly solvable model of reversible adsorption on a disordered substrate [PDF]
, 2007 We consider the reversible adsorption of dimers on a regular lattice, where adsorption occurs on a finite fraction of sites selected randomly. By comparing this system to the pure system where all sites are available for adsorption, we show that when the activity goes to infinity, there exists a mapping between this model and the pure system at the ...
arxiv +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Molecules, 2011 In the present study, anti-IBV (infectious bronchitis virus) activities of (-)-pinenes were studied by MTT assay, as well as docking and molecular dynamic (MD) simulations. The CC50 values of (-)-α-pinene and (-)-β-pinene were above 10 mM.
Zhiwei Yang +3 more
doaj +1 more source
Criticality of a dissipative self-organizing process in a dynamic population [PDF]
arXiv, 2006 We derive a general formulation of the self-organized branching process by considering sandpile dynamics in an evolving population characterized by "birth" (excitation) and "death" (de-excitation) of active sites ($z=1$). New active sites are born in empty sites ($z=0$) with a probability of $\eta$, whereas active sites die, thus becoming empty, with a
arxiv