Results 121 to 130 of about 1,259,380 (310)
Frontiers in PharmacologyIntroductionSemen Cuscutae is a traditional Chinese medicine (TCM) that tonifies the kidneys and prevents miscarriage. According to Chinese medicine theory, kidney deficiency is one of the main causes of recurrent spontaneous abortion (RSA). The previous
Zhitong Yang +16 more
doaj +1 more source
EFEK ANTIMIKROBA EKSTRAK BATANG KAYU MANIS (Cinnamomun burmanni) TERHADAP Salmonella typhi [PDF]
, 2009 Salmonella typhi is enteropatogenik organism that cause typhoid fever which stiil can be epidemologic problem in the world. The first drug of choice for Salmonella typhi is chloramphenikol.
WIDYASTUTI, RIRIN
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Significance of Non-ergodicity Property of Statistical Mechanics Systems for Understanding Resting State of a Living Cell [PDF]
, 2010 A better grasp of the physical foundations of life is necessary before we can understand the processes occurring inside a living cell. In his physical theory of the cell, American physiologist Gilbert Ling introduced an important notion of the resting ...
Matveev, V. V., Prokhorenko, D. V.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Hazardous substances and activities
, 2003 Introduction International environmental law has tended to regulate specific environmental media and/or resources rather than particular activities or products. There is, however, a significant emerging body of rules which regulate those activities or products considered by the international community, within a region or globally, to be hazardous or ...
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Theory formation by abduction : a case study based on the chemical revolution [PDF]
, 1990 Abduction is the process of constructing explanations. This chapter suggests that automated abduction is a key to advancing beyond the "routine theory revision" methods developed in early AI research towards automated reasoning systems capable of "world ...
Morris, Steven +2 more
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source