Pigment epithelium-derived factor (PEDF) interacts with transportin SR2, and active nuclear import is facilitated by a novel nuclear localization motif. [PDF]
PLoS ONE, 2011 PEDF (Pigment epithelium-derived factor) is a non-inhibitory member of the serpin gene family (serpinF1) that displays neurotrophic and anti-angiogenic properties.
Sergio Anguissola +5 more
doaj +1 more source
Biohybrid active matter -- the emergent properties of cell-mediated microtransport [PDF]
Phys. Rev. Applied 18 (2022) 034014, 2021 As society paves its way towards device miniaturization and precision medicine, micro-scale actuation and guided transport become increasingly prominent research fields with high impact in both technological and clinical contexts. In order to accomplish directed motion of micron-sized objects towards specific target sites, active biohybrid transport ...
arxiv +1 more source
Nucleocytoplasmic distribution and dynamics of the autophagosome marker EGFP-LC3. [PDF]
PLoS ONE, 2010 The process of autophagy involves the formation of autophagosomes, double-membrane structures that encapsulate cytosol. Microtubule-associated protein light chain 3 (LC3) was the first protein shown to specifically label autophagosomal membranes in ...
Kimberly R Drake +2 more
doaj +1 more source
Cytoplasmic Flow and Mixing Due to Deformation of Motile Cells. [PDF]
, 2017 The cytoplasm of a living cell is a dynamic environment through which intracellular components must move and mix. In motile, rapidly deforming cells such as human neutrophils, bulk cytoplasmic flow couples cell deformation to the transport and dispersion
Chan, Caleb K +2 more
core +2 more sources
Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization. [PDF]
PLoS ONE, 2010 BACKGROUND: Nucleolin is one of the major proteins of the nucleolus, but it is also expressed on the cell surface where is serves as a binding protein for variety of ligands implicated in tumorigenesis and angiogenesis.
Ara G Hovanessian +5 more
doaj +1 more source
An update on nuclear calcium signalling [PDF]
, 2009 Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca2+) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca2+ activity, and vice versa. In this
Bootman, Martin D. +4 more
core +1 more source
Exploring the cellular accumulation of metal complexes [PDF]
, 2010 Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell.
Barton, Jacqueline K. +2 more
core +1 more source
Cells, 2020 Background: The central channel of the nuclear pore complex plays an important role in the selective transport of proteins between the nucleus and cytoplasm.
Ryotaro Okazaki +2 more
doaj +1 more source
Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB. [PDF]
PLoS ONE, 2013 Leishmania donovani, the causative organism for visceral leishmaniasis, contains a unique heterodimeric DNA-topoisomerase IB (LdTopIB). LdTopIB is a heterodimer made up of a large subunit and a small subunit that must interact with each other to build an
Christopher F Prada +5 more
doaj +1 more source
Cytoskeletal network morphology regulates intracellular transport dynamics [PDF]
Biophysical Journal, 109(8), 1574 (2015), 2016 Intracellular transport is essential for maintaining proper cellular function in most eukaryotic cells, with perturbations in active transport resulting in several types of disease. Efficient delivery of critical cargos to specific locations is accomplished through a combination of passive diffusion and active transport by molecular motors that ...
arxiv +1 more source