Results 91 to 100 of about 4,303,904 (295)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Les interventions des villes en faveur de la mobilité active et l’impératif de l’acceptabilité sociale

VertigO
This article puts into perspective the notion of social acceptability regarding urban redevelopment projects which reallocate part of the roadway for pedestrians and cyclists.
Myriam Guillemette, Sophie Paquin
doaj   +1 more source

Impact of travel mode shift and trip distance on active and non-active transportation in the São Paulo Metropolitan Area in Brazil

Preventive Medicine Reports, 2015
Background: Changes in urban mobility play a major role in transforming metropolitan areas into healthier places. This study quantified the impact of changes in travel mode shift and trip distance on active and non-active transportation of working age ...
Thiago Hérick de Sá, Diana C. Parra, Carlos Augusto Monteiro   +2 more
doaj   +1 more source

Energetics of Active Transport Processes

Biophysical Journal, 1968
Discussions of active transport usually assume stoichiometry between the rate of transport J(+) and the metabolic rate J(r). However, the observation of a linear relationship between J(+) and J(r) does not imply a stoichiometric relationship, i.e., complete coupling.
Essig, A., Caplan, S.R.
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Transportation Acronym Guide, 1996

KB601/K6004This report compiles and identifies transportation and transportation-related acronyms throughout the Department of Transportation and other related U.S. government agencies. This is the second edition of the Transportation Acronym Guide (TAG);
Feldman, Richard N., Gross, Marilyn, John A. Volpe National Transportation Systems Center (U.S.)   +2 more
core   +1 more source

Understanding and Systematizing Challenges in Dockless Bike-Sharing: The Case of the Federal University of Rio de Janeiro

Applied Sciences
This study investigates the challenges associated with dockless bike-sharing systems through a systematic literature review combined with a case study of the Integra UFRJ project, implemented at the Federal University of Rio de Janeiro. The research aims
Gabriel Bezerra Costa de Lima, Victor Hugo Souza de Abreu, Marcio de Almeida D’Agosto   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Long-range transportation plan

, 2004
Cover title.; "Prepared by State of Connecticut, Department of Transportation, Bureau of Policy & Planning ... ; in cooperation with U.S. Department of Transportation, Federal Highway Administration and the Federal Transit Administration"--Table of ...
Connecticut. Dept. of Transportation.
core