Results 151 to 160 of about 59,022 (255)

The Interplay Between IL‐6, Hepcidin, and BMPR2 Signalling in Pulmonary Arterial Hypertension: Mechanistic Insights Into Vascular Remodelling

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary vasoconstriction and vascular remodelling, with mutations in bone morphogenetic protein receptor type 2 (BMPR2) being the most common genetic alteration associated with the disease.
Quezia K. Toe, Theo Issitt, Gregory J. Quinlan, S. John Wort   +3 more
wiley   +1 more source

Lifesaving Compassionate‐Use of Sotatercept in a 12‐Year‐old With Idiopathic Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Pediatric idiopathic pulmonary arterial hypertension (IPAH) refractory to maximal medical therapy is associated with high morbidity and mortality, and therapeutic options remain limited. We describe a 12‐year‐old girl with end‐stage IPAH who developed acute decompensated right heart failure despite triple combination therapy, including high ...
Weronika Pelczar‐Płachta, Rafał Surmacz, Waldemar Bobkowski   +2 more
wiley   +1 more source

Nintedanib Lacks Efficacy in a Spirometry‐Confirmed and Bleomycin‐Induced Mouse Model of Idiopathic Pulmonary Fibrosis

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three independent treatment intervention studies in the single‐dose bleomycin (BLEO) mouse model of IPF.
Jamal Bousamaki, Grzegorz Maciag, Asbjørn Graver Petersen, Stefanie H. Korntner, Stine Marie Jansen, Susanne E. Pors, Linn Salto Mamsen, Silas A. Rasmussen, Casper Gravesen Salinas, Louise Humle Kruse, Michael Feigh, Ulf Simonsen, Henrik H. Hansen   +12 more
wiley   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, Volume 59, Issue 4, April 2026.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Transcriptome Comparison Between the Cultured and In Vivo Chick Primordial Germ Cells by SMART‐Seq‐Based Single‐Cell RNA Sequencing

Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.
Cultivation of PGCs triggers a transition from MYC‐ to MYCN‐driven transcriptional regulation. ABSTRACT Primordial germ cells (PGCs), the precursors of the germline, have unique cellular characteristics to undergo long‐distance migration to the embryonic gonads and have the potential to differentiate into somatic cells. Among the animal models studying
Yoshiki Hayashi, Atsushi Doi, Hiroko Iikawa, Hirokazu Kimijima, Yutaka Suzuki, Akinori Kanai, Hideki Hirakawa, Daisuke Saito   +7 more
wiley   +1 more source

Understanding Impact of Anti‐Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods

Obesity Reviews, Volume 27, Issue 4, April 2026.
ABSTRACT Anti‐obesity medications promote greater degrees of weight loss than lifestyle interventions alone. There is an important need to understand whether loss of skeletal muscle during pharmacologically induced weight loss is clinically significant due to its essential role in health and disease.
Arden McMath, Dympna Gallagher
wiley   +1 more source

Circulating Activin A and Follistatin-like Proteins in Rheumatoid Arthritis with Interstitial Lung Disease: A Cross-Sectional Comparative Study. [PDF]

Diagnostics (Basel)
Ulutaş F, Kaya K, Yiğit N, Çobankara V.   +3 more
europepmc   +1 more source

Effects of varying concentrations of Ubiquinol (coenzyme Q10) on physiological parameters in male donkeys (<i>Equus asinus</i>). [PDF]

Front Vet Sci
Akhtar MF, Umar M, Changfa W.
europepmc   +1 more source

Spinal cord injury-induced overflow incontinence reshapes the activin-follistatin-inhibin axis in mouse bladder and kidney. [PDF]

Front Mol Biosci
Shen Y, Yang S, Zhou H, Zhu Y, Wang Z, Jiang W.   +5 more
europepmc   +1 more source

BMPR2 Dosage Gates BMP9/10 Signaling Output in Pulmonary Artery Endothelium. [PDF]

Cells
Chu KY, Thamilselvan V, Crawford AN, Yu PB, Martinez-Hackert E.   +4 more
europepmc   +1 more source