Results 91 to 100 of about 16,937,312 (352)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The disrupted jet stream and its influence on flight time during solar proton events

Scientific Reports
The long-chain effects of eruptive solar activities on Earth’s magnetosphere, ionosphere, and the mid-to-lower atmospheric circulation are an important theoretical research topic in the fields of space weather and atmospheric science.
Xiaoheng Xu, Yi Wang, Fengsi Wei, Xueshang Feng, Manhui Bo, Hongwu Tang, Diansheng Wang, Lei Bian, Boyi Wang, Pingbing Zuo, Chaowei Jiang, Xiaojun Xu, Zilu Zhou, Zeng Li, Peng Zou, Yun Li, Liang Zeng, Xiaoxing Zhu   +17 more
doaj   +1 more source

Investigation of Travel and Activity Patterns Using Location-based Social Network Data: A Case Study of Active Mobile Social Media Users

ISPRS International Journal of Geo-Information, 2015
Due to its relatively high availability and low cost, location-based social network (LBSN) (e.g., Foursquare) data (a popular type of volunteered geographic information) seem to be an alternative or complement to survey data in the study of travel ...
Yeran Sun, Ming Li
doaj   +1 more source

Information and propaganda activities of Religious Communities in the Internet Space

, 2022
K. Nazarbek
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Mathematical expressions of the drag-based models for predicting the arrival time of coronal mass ejection and their development and evolutionary processes

Frontiers in Astronomy and Space Sciences
As one of the most violent solar activities, coronal mass ejections (CMEs) are eruptions of the large-scale magnetized plasma from the Sun’s upper atmosphere into interplanetary space.
Xinhua Zhao, Chenyu Shi, Chenyu Shi, Chenyu Shi, Xiao Liu, Xueshang Feng, Xueshang Feng, Yufen Zhou, Nanbin Xiang, Nanbin Xiang, Linhua Deng, Alexey Kuznetsov, Christian Möstl   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparative Study of the Single‐Event Functional Interrupt (SEFI) Rate in Solid‐State Drives (SSD) Through Ground and On‐Orbit Testing

Space Weather
Space radiation poses a significant threat to the reliability of spacecraft equipment, while traditional static space environment models exhibit substantial inaccuracies in calculating on‐orbit error rates. This study investigates single‐event functional
Yingqi Ma, Tian Yu, Xiaoheng Xu, Peng Guo, Chunqin Wang, Guohong Shen, Zhikang Fu, Longlong Zhang, Jieyi Wang, Bo Yang, Yunziwei Deng, Qiang Li, Long Zhang   +12 more
doaj   +1 more source

Research on Removing Thin Cloud Interference in Solar Flare Monitoring with SMAT-Configured Telescopes

Universe
The precise monitoring of solar flares holds significant scientific value for space mission safety, communication security, and space environment forecasting.
Hongyan Li, Shangbin Yang, Xing Hu, Haiqing Xu   +3 more
doaj   +1 more source