Results 81 to 90 of about 3,931,453 (288)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Situating partnership activity, an activity theory inspired analysis of school to school inquiry networks

Cogent Education, 2019
The issue of how schools work in partnership with each other and with other organisations has always been of interest to school leaders, policymakers, and practitioners.
Andrew Townsend
doaj   +1 more source

New academics’ experiences of induction to teaching: an Activity Theory approach [PDF]

, 2019
In this article we present findings of a research project investigating the experiences of new academics in the process of becoming effective teachers, using an Activity Theory framework (Engestrom, 2001 ).
Allin, Linda, Anderson, Emma, Black, Kate, Hooper, Helen, Mathieson, Susan, Mcinnes, Lynn, Orme, Elizabeth, Penlington, Roger   +7 more
core  

Towards understanding dynamo action in M dwarfs

, 2015
Recent progress in observational studies of magnetic activity in M dwarfs urgently requires support from ideas of stellar dynamo theory. We propose a strategy to connect observational and theoretical studies.
Kitchatinov, L., Moss, D., Shulyak, D., Sokoloff, D.   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Organizational Boundary Crossing Actions and Optimization Strategies in the Implementation of the "National Excellent Primary and Secondary School Teacher Training Program ": From the Perspective of Activity Theory

Jiaoshi jiaoyu xuebao
In July 2023, China issued the Opinions of the Ministry of Education on Implementing the National Excellent Primary and Secondary School Teacher Training Plan, which requires the implementation of the "National Excellent Primary and Secondary School ...
CAO Taisheng, ZHAI Chenqi
doaj   +1 more source

Metastability, Criticality and Phase Transitions in brain and its Models [PDF]

, 2006
This essay extends the previously deposited paper "Oscillations, Metastability and Phase Transitions" to incorporate the theory of Self-organizing Criticality.
Werner, MD Gerhard
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source