Results 51 to 60 of about 5,402,583 (289)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
ANALYSIS OF THE ACTUAL STATE LUBRICANT TO RESOURCE ELEMENTS CRUSHING AND GRINDING MACHINERY
Вестник СибАДИ, 2017 The probabilistic nature of resource allocation units, assembly units and parts of machines and equipment, including crushing and grinding, detects the presence of certain reserves in the improvement of preventive work the system for maintenance and ...
V. N. Kuznetsova, Ya. V. Yarmovich
doaj +1 more source
The actual state of the geodetic and cartographic resources and legislation in Poland
Open Geosciences, 2023 Official data, including national geodetic and cartographic resources, are integrated in a spatial reference system. This study outlines national resources in Poland as an important part of the spatial information infrastructure in the European Community.
Doskocz Adam
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
State Contract and Value Added Tax: Actual Issues of Judicial Practices
Управленческое консультирование, 2018 The article is devoted to the legal analysis of legislation and judicial practices in the field of public procurement. Over recent years increasing attention is paid to relations in the sphere of procurement of goods, performance of works, rendering of ...
Alina Vladimirovna Kostyukova +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
“Actual” and “Constructive” Possession in Alaska: Clarifying the Doctrine [PDF]
, 2019 In two cases, one recent and one now nearly a decade old, Judge David Mannheimer has raised important questions about Alaska’s jury instruction on “possession.” In particular, Judge Mannheimer has expressed a worry that Alaska’s definition of ...
Flanders, Chad
core +1 more source
Experimental Polarization State Tomography using Optimal Polarimeters
, 2006 We report on the experimental implementation of a polarimeter based on a scheme known to be optimal for obtaining the polarization vector of ensembles of spin-1/2 quantum systems, and the alignment procedure for this polarimeter is discussed.
Alexander Ling +8 more
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source