Results 211 to 220 of about 950,229 (336)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Comparative Analysis of Acute-Phase Protein Profiles in Cats Undergoing Ovariectomy: Laparoscopic vs. Conventional Surgery in Short Time After Procedure. [PDF]

Animals (Basel)
Cuervo B, Satué K, Velasco-Martínez MG, Sopena JJ, Carrillo JM, Damiá E, Chicharro D, Peláez P, Martins E, García-Martínez JD, Rubio M.   +10 more
europepmc   +1 more source

Complement regulation in innate immunity and the acute-phase response: inhibition of mannan-binding lectin-initiated complement cytolysis by C-reactive protein (CRP) [PDF]

, 1998
Chusana Suankratay, Carolyn Mold, Y Zhang, Lawrence A. Potempa, Thomas F. Lint, H Gewurz   +5 more
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Association of results of the glutaraldehyde coagulation test with plasma acute phase protein concentrations and hematologic findings in hospitalized cows. [PDF]

Front Vet Sci
Trefz FM, Balmer M, Peters LM, Bruckmaier RM, Meylan M.   +4 more
europepmc   +1 more source

Cutting Edge: The Induction of Acute Phase Proteins by Lipopolysaccharide Uses a Novel Pathway That Is CD14-Independent [PDF]

, 1998
Alain Haziot, Xing Y. Lin, Fan Zhang, Sanna M. Goyert   +3 more
openalex   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Acute Phase Proteins - Regulation and Functions of Acute Phase Proteins

, 2011
openaire   +3 more sources

A dual strain probiotic administered via the waterline beneficially modulates the ileal and cecal microbiome, sIgA and acute phase protein levels, and growth performance of broilers during a dysbacteriosis challenge. [PDF]

Poult Sci
van der Klein SAS, Arora SS, Haldar S, Dhara AK, Gibbs K.   +4 more
europepmc   +1 more source

Higher circulating orosomucoid, an acute-phase protein, and reduced glucose-induced insulin secretion in middle-aged Japanese people with prediabetes. [PDF]

BMJ Open Diabetes Res Care, 2020
Tsuboi A, Kitaoka K, Yano M, Takeuchi M, Minato-Inokawa S, Honda M, Kurata M, Wu B, Kazumi T, Fukuo K.   +9 more
europepmc   +1 more source