Results 61 to 70 of about 975,400 (335)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration

, 2013
Prion diseases are characterized by accumulation of misfolded protein, gliosis, synaptic dysfunction, and ultimately neuronal loss. This sequence, mirroring key features of Alzheimer disease, is modeled well in ME7 prion disease.
Asuni, Ayodeji A, Bailey, Joanne, Gray, Bryony, O'Connor, Vincent, Perry, V Hugh, Skipp, Paul   +5 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig [PDF]

, 2005
Peer reviewedPublisher ...
Andresen, L O, Campbell, Fiona Margaret, Eckersall, P D, Heegaard, P M H, Sorensen, N S, Waterston, M   +5 more
core   +3 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Exploring the Relationship between Canine Paraoxonase-1 (PON-1) Serum Activity and Liver Disease Classified by Clinico-Pathological Evaluation

Animals
Paraoxonase-1 (PON-1), a liver-synthesized enzyme, acts as a negative acute-phase reactant during systemic inflammation in dogs. Given the hepatic synthesis of this enzyme, the presence of liver diseases may influence PON-1, thus affecting its ...
Sara Meazzi, Sabiha Zarin Tasnim Bristi, Virginia Bianchini, Paola Scarpa, Alessia Giordano   +4 more
doaj   +1 more source

Pediatric nephrotic syndrome: The interplay of oxidative stress and inflammation [PDF]

Journal of Medical Biochemistry
Background: The pathophysiological mechanisms crucial in the development of nephrotic syndrome (NS) in the pediatric population are still not fully understood.
Mulat Simachew Yonas, Mihajlović Marija, Antonić Tamara, Miloševski-Lomić Gordana, Peco-Antić Amira, Jovanović Dragana, Paripović Dušan, Stefanović Aleksandra   +7 more
doaj   +1 more source

Multi-walled carbon nanotube-physicochemical properties predict the systemic acute phase response following pulmonary exposure in mice. [PDF]

PLoS ONE, 2017
Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) has been linked to an increased risk of developing cardiovascular disease in addition to the well-documented physicochemical-dependent adverse lung effects.
Sarah S Poulsen, Kristina B Knudsen, Petra Jackson, Ingrid E K Weydahl, Anne T Saber, Håkan Wallin, Ulla Vogel   +6 more
doaj   +1 more source

Acute Phase Proteins in Animals

, 2012
Acute phase proteins (APP) were first identified in the early 1900s as early reactants to infectious disease. They are now understood to be an integral part of the acute phase response (APR) which is the cornerstone of innate immunity. APP have been shown to be valuable biomarkers as increases can occur with inflammation, infection, neoplasia, stress ...
openaire   +3 more sources

Phylogeny and expression analysis of C-reactive protein (CRP) and serum amyloid-P (SAP) like genes reveal two distinct groups in fish [PDF]

, 2017
This work was funded by British Society of Animal Science/Genesis Faraday to both SAM and SB Immune control of energy reallocation in fish and a BBSRC Research Experience Placements (2010).Peer reviewedPublisher ...
Badolato, Baldo, Cray, Garlanda, Gerwick, Gisladottir, Goujon, Hind, J. Zou, Jensen, Jørgensen, Kodama, Kovacevic, Lee, Letunic, Lien, Louis, Lund, Lund, MacCarthy, Mantovani, Marsden, Martin, Nguyen, P.T. Lee, Patel, Pepys, Pepys, Rebl, Rubio, S. Bird, S.A.M. Martin, Schwalbe, Shah, Shrive, Steel, Tamura, Tennent, Urieli-Shoval, Villarroel, Zou, Zou   +41 more
core   +1 more source