Results 11 to 20 of about 435,097 (243)
A prospective study of nutritional status in immunoglobulin light chain amyloidosis
Haematologica, 2013 Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome.
Prayman T. Sattianayagam +12 more
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Analysis of Cardiac Amyloidosis Progression Using Model-Based Markers
Frontiers in Physiology, 2020 Deposition of amyloid in the heart can lead to cardiac dilation and impair its pumping ability. This ultimately leads to heart failure with worsening symptoms of breathlessness and fatigue due to the progressive loss of elasticity of the myocardium ...
Wenguang Li +11 more
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Clinical profile and treatment outcome of older (>75 years) patients with systemic AL amyloidosis
Haematologica, 2015 Systemic AL amyloidosis, a disease with improving outcomes using novel therapies, is increasingly recognized in the elderly but treatment and outcomes have not been systematically studied in this group of patients in whom comorbidities and frailty may ...
Sajitha Sachchithanantham +10 more
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Scientific Reports, 2021 Hereditary transthyretin-mediated (hATTR) amyloidosis is an underdiagnosed, progressively debilitating disease caused by mutations in the transthyretin (TTR) gene.
Margaret M. Parker +21 more
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C. elegans feed yolk to their young in a form of primitive lactation
Nature Communications, 2021 It is unclear why C. elegans continues to produce large quantities of yolk after reproduction. Here the authors show that post-reproductive C. elegans mothers vent yolk which supports their offspring’s growth, serving as a form of primitive lactation.
Carina C. Kern +8 more
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Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis
Kidney International Reports, 2019 Introduction: Hereditary fibrinogen Aα-chain (AFib) amyloidosis is a relatively uncommon renal disease associated with a small number of pathogenic fibrinogen Aα (FibA) variants; wild-type FibA normally does not result in amyloid deposition.
Graham W. Taylor +11 more
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The importance of acute-phase proteins as markers in cancers
Studia Medyczne, 2021 Acute-phase proteins (APPs) form a group of heterogeneous proteins whose synthesis takes place in the liver. This involves mediators such as cytokines and constitutes a response to acute inflammations, bacterial infections, tumours, and autoimmune ...
Paulina Zegarska +2 more
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Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein
Kidney International Reports, 2017 Fibrinogen A alpha chain amyloidosis is an autosomal dominant disease associated with mutations in the fibrinogen A alpha chain (FGA) gene, and it is the most common cause of hereditary renal amyloidosis in the UK.
Dorota Rowczenio +18 more
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Scientific Reports, 2017 Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds ...
Guglielmo Verona +11 more
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Acute phase proteins in sheep and goats – function, reference ranges and assessment methods: An overview [PDF]
Bulgarian Journal of Veterinary Medicine, 2018 Acute phase response (APR) is activated by disorders in systemic homeostasis. The main purpose of APR is to prevent further tissue damage by isolation and destruction of causative agent, removing the toxic products and providing conditions for tissue ...
P. Iliev, T. Mircheva-Georgieva
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