Results 71 to 80 of about 1,149,987 (297)

SERUM AMYLOID A IN RUMINANTS: DIAGNOSTIC VALUE AND FOOD CONTAMINATION ASSESSMENT [PDF]

, 2010
The aims of the work presented in this thesis were to investigate the bovine acute phase protein Serum Amyloid A, focussing on its value as safety marker in farm animals. SAA can be considered as a natural anti-inflammatory and immunomodulatory agent
L.F. Pisani
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effects of meeting the requirements in energy and protein, and of systemic inflammation on the interval from parturition to conception in dairy cows

Czech Journal of Animal Science, 2018
Main aim of this retrospective study was to determine the role of the level of meeting the requirements in net energy of lactation (NEL) and utilizable crude protein at the duodenum (uCP) in weeks 3-17 postpartum on the interval from parturition until ...
Elke Humer, Leonhard Gruber, Qendrim Zebeli   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Proteomic profiling of the plasma of Gambian children with cerebral malaria

Malaria Journal, 2018
Background Cerebral malaria (CM) is a severe neurological complication of Plasmodium falciparum infection. A number of pathological findings have been correlated with pediatric CM including sequestration, platelet accumulation, petechial haemorrhage and ...
Ehab M. Moussa, Honglei Huang, Marie L. Thézénas, Roman Fischer, Abhinay Ramaprasad, Fatou Sisay-Joof, Muminatou Jallow, Arnab Pain, Dominic Kwiatkowski, Benedikt M. Kessler, Climent Casals-Pascual   +10 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Gamma-delta T lymphocytes and 25-hydroxy vitamin D levels as key factors in autoimmunity and inflammation : the case of zoledronic acid-induced acute phase reaction

, 2015
Zoledronic acid (ZA) infusion for osteoporosis is frequently associated with the onset of an acute phase reaction (APR) secondary to the activation of γδ T cell receptor (TCR) lymphocytes (γδ T cells) and to low vitamin D levels, similar to what is ...
A. Ceribelli, M. De Santis, G. Fabbriciani, F. Cavaciocchi, C. Selmi, M. Massarotti, C. Crotti, E. Generali   +7 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Short‐term effects of the TNFα antagonist infliximab on the acute phase reaction and activities of daily life in patients with rheumatoid arthritis

, 2007
Objective. To investigate the short-term effects of the tumour necrosis factor alpha (TNFα) antagonist infliximab on the acute phase reaction and activities of daily life (ADL) in patients with rheumatoid arthritis (RA). Methods.
Larsson, Anders,, A. Larsen, Arvidson, Nils Gunnar,, A. Larsson, Larsen, A., N. G. Arvidson, Aaseth, J., J. Aaseth   +7 more
core   +1 more source

ACTIVITY OF LYSOZYME IN THE BLOOD OF MONTH RATS AFTER ACUTE SOMATIC PAIN

Медицинский вестник Юга России, 2014
Purpose: to study activity of lysozyme in the blood of month rats after acute somatic pain.Materials and methods: Experiments were conducted on white month non-linear rats.
V. G. Ovsyannikov, A. E. Boychenko, V. V. Alekseev, N. S. Alekseeva, M. V. Abramova, V. E. Nikolaev   +5 more
doaj   +1 more source