Results 81 to 90 of about 6,617 (217)

Nonsteroidal Anti‐Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) may mitigate periodontal tissue breakdown through cyclooxygenase (COX) inhibition; however, their long‐term effects on the risk of periodontitis remain unclear. Methods We emulated target trials using US electronic health records (1995–2019) to compare the 5‐year risk of incident ...
Ignacio Leiva‐Escobar, Aiswarya Puzhakkara Chennas, Zoheir Alayash, Stefan Lars Reckelkamm, Birte Holtfreter, Thomas Kocher, Sebastian‐Edgar Baumeister, Michael Nolde   +7 more
wiley   +1 more source

Risk of urinary tract infection with SGLT2 inhibitor initiation in patients with immune‐mediated inflammatory diseases and type 2 diabetes: A target trial emulation using a Japanese hospital‐based claims database

Journal of Diabetes Investigation, EarlyView.
In this target trial emulation of patients with immune‐mediated inflammatory diseases and type 2 diabetes, SGLT2 inhibitor initiation was not associated with a clear increase in UTI risk versus metformin, including across immunosuppressive therapy strata.
Hiroshi Tsushima, Nobuyuki Yajima, Takashi Nomiyama, Ryoko Sakai, Hisashi Noma, Akira Katagiri, Naoto Tamura   +6 more
wiley   +1 more source

Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis.

PLoS ONE, 2017
BackgroundGout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals.
Jin-Hui Tao, Miao Cheng, Jiang-Ping Tang, Xiao-Juan Dai, Yong Zhang, Xiang-Pei Li, Qin Liu, Ya-Ling Wang   +7 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Acute gouty arthritis as a manifestation of immune reconstitution inflammatory syndrome after initiation of antiretroviral therapy [PDF]

, 2012
Immune reconstitution inflammatory syndrome (IRIS) in HIV-infected subjects initiating antiretroviral therapy most commonly involves new or worsening manifestations of previously subclinical or overt infectious diseases.
Carlos Alberto Morais-de-Sá, Walter de Araujo Eyer-Silva, Rogério Neves-Motta, Maria Cecília da Fonseca Salgado, Fernando Raphael de Almeida Ferry, Marcelo Costa Velho Mendes de Azevedo, Jorge Francisco da Cunha Pinto   +6 more
core   +1 more source

Serum Uric acid level during the acute attacks of Gouty arthritis

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2003
Background and Objective: Gout is a condition characterized by acute arthritis and hyperuricemia, but the prevalence of hyperuricemia and the level of serum uric acid (SUA) in acute gout is not known exactly.
B Heidari, KH Bijani, SH Savad Koohi, E Shafigh   +3 more
doaj  

Is It Safe to Implant Prosthesis When Frozen Section Reports Positive During Joint Arthroplasty? A Retrospective Cohort Study

Orthopaedic Surgery, EarlyView.
This study demonstrated that it is improper to overinterpret isolated frozen section positivity. It may be safe to implant prosthesis in patients who had positive frozen sections but without other signs of infection. Surgeons opting for staged revisions solely based on neutrophil counts risk unnecessary morbidity, particularly in patients with ...
Chiyuan Ma, Pingan Lin, Lingyun Wu, Jieli Zhou, Jiaxuan Zou, Pengfei Hu, Lidong Wu, Haobo Wu   +7 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

A rare and asymptomatic case of mitral valve tophus associated with severe gouty tophaceous arthritis

, 2004
Gouty arthritis is characterized by the deposition of monosodium urate crystals in the joints and soft tissues. Clinical manifestations include acute and chronic arthritis and tophaceous deposits.
Iacobellis, G
core   +1 more source

What makes gouty inflammation so variable?

BMC Medicine, 2017
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Robert Terkeltaub
doaj   +1 more source