Results 71 to 80 of about 6,617 (217)

Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample.

, 2016
INTRODUCTION: Studies describing seasonal variations in acute gouty arthritis note seasonal variation, but disagree on timing, with most showing a peak in spring months while others show peaks later in the year.
Aryal, Madan Raj, Donato, Anthony A., Karmacharya, Paras, Giri, Smith, Pathak, Ranjan   +4 more
core   +1 more source

The Human and Economic Burden of Difficult-to-Treat Gouty Arthritis [PDF]

, 2015
Gouty arthritis, one of the most painful and common forms of adult arthritis, is caused by monosodium urate crystal deposits in joints, most often in the lower extremities.
Oude Voshaar, Martijn A.H., Bardin, Thomas, van de Laar, Mart A.F.J.   +2 more
core   +1 more source

Advances in the study of gut microecology and mechanisms of hyperuricemia and gouty arthritis

Frontiers in Immunology
Gouty arthritis is a metabolic disorder caused by purine metabolism dysregulation, characterized by monosodium urate crystal deposition in and around joints, triggering acute articular inflammation via NLRP3 inflammasome activation and IL-1β-mediated ...
Youliang Zhang, Hengyu Zhang, Tianwen Miao, Xuetao Wang, Yanan Zuo, Renwei Zhang, Liangtong Zhang, Yuan Cheng, Dong Liu, Xin Chen, Xin Chen, Longcan Li, Xingwen Xie, Xingwen Xie, Ning Li, Ning Li   +15 more
doaj   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study

, 2010
OBJECTIVE: To assess the efficacy and tolerability of canakinumab, a fully human anti-interleukin-1β monoclonal antibody, for the treatment of acute gouty arthritis.
Yücel, A.E., De Meulemeester, M., Valda Murphy, Pikhlak, A., Andrey Pikhlak, Arulmani, U., Peter Sallstig, Dominik Richard, Udayasankar Arulmani, So, A., Murphy, V., A. Eftal Yücel, Naomi Schlesinger, Marc De Meulemeester, Schlesinger, N., Richard, D., Alexander So, Sallstig, P.   +17 more
core   +1 more source

Bio‐Propelled Stomatocyte Nanomotors with Glutathione‐Responsiveness for Osteoarthritis Treatment

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
Glutathione (GSH)‐responsive stomatocyte nanomotors with encapsulated MTX utilize oxygen to achieve autonomous motion and undergo GSH‐induced dissociation, enhancing cellular uptake, tissue penetration, and MTX release within the osteoarthritis (OA) region, thereby improving therapeutic efficacy.
Jianhong Wang, Mengsi Zhan, Hanglong Wu, Maarten Bransen, Ioanna Balmpouzi, Xianwen Lou, Junjie Liu, Nina Wang, Zhiqiang Wang, Heiner Friedrich, Jingxin Shao, Jan C. M. van Hest, Xiangyang Shi   +12 more
wiley   +2 more sources

Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome

Arthritis Research & Therapy, 2018
Background MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the peripheral blood mononuclear cells
Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-shuang Liu, Qing-Sheng Mi, Jing-Guo Zhou   +6 more
doaj   +1 more source

What Fat Is That? Scanning Perirenal Fat: A Survey of Australasian Sonographers

Journal of Medical Radiation Sciences, EarlyView.
What fat is that? Ultrasound measurement of perirenal adipose tissue and CVD. Results of a survey of Australasian sonographers 2024. ABSTRACT Introduction Ultrasound measures of perirenal adipose tissue (PRAT) have emerged as potentially efficient, cost‐effective, and accessible methods for assessing cardiovascular disease (CVD) risk.
Victoria Baumann, Richard Banati, Jillian Clarke   +2 more
wiley   +1 more source

Efficacy of Anakinra for Various Types of Crystal-Induced Arthritis in Complex Hospitalized Patients: A Case Series and Review of the Literature

Mediators of Inflammation, 2015
Background. There are few data on anakinra use after failure of conventional medications for crystal-induced peripheral arthritis and/or crowned dens syndrome among complex hospitalized patients. Methods.
A. Aouba, S. Deshayes, L. Frenzel, A. Decottignies, C. Pressiat, B. Bienvenu, F. Boue, G. Damaj, O. Hermine, S. Georgin-Lavialle   +9 more
doaj   +1 more source

Effect of Acupuncture on Rats with Acute Gouty Arthritis Inflammation: A Metabonomic Method for Profiling of Both Urine and Plasma Metabolic Perturbation

, 2011
Acute gouty arthritis is a common inflammation model with multiple pathogenic mechanisms seen in clinical practice, for which acupuncture may potentially be an alternative therapy.
Si-Lan Wen, Yu-Jie Liu, Liu Zhang, Hai-Lin Yin, Hong-Yuan Zhu, Jin Xiao, Jin-Tao Xue, Li-Ming Ye   +7 more
core   +1 more source