Results 51 to 60 of about 6,617 (217)

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Biomimetic Nanoparticle Delivering Colchicine to Target Endothelial Inflammation for Atherosclerosis Treatment

Advanced NanoBiomed Research, EarlyView.
Platelet membrane‐coated layered double hydroxide nanoparticles were engineered to target inflamed endothelium at early‐stage atherosclerosis and enhance therapeutic efficacy. The biomimetic platform improves stability, immune escape, and inflamed vascular cell targeting, resulting in reduced oxidative stress and downregulated adhesion molecules.
Xiuwen Zhang, Lingqing Zong, Ashish Misra, Sanjay Patel, Zi Gu   +4 more
wiley   +1 more source

Lower Satisfaction and Inferior Outcomes Associated With Delayed Surgery for Chronic Quadriceps Tendon Ruptures: A Systematic Review

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the literature regarding the efficacy of various repair and reconstruction surgical techniques for chronic quadriceps tendon ruptures (QTRs) in native knees and to assess their associated outcomes. Methods A comprehensive literature search of the EMBASE, PubMed/MEDLINE, and Cochrane databases was conducted from October 2023 to ...
Matthew R. Bryan, Michael Mazzucco, Arsen Omurzakov, Alex E. White, Prashanth Kumar, Tyler Uppstrom, Nicolas Pascual‐Leone, Stephen O’Brien, Samuel A. Taylor   +8 more
wiley   +1 more source

ATP-Activated P2X7R Promote the Attack of Acute Gouty Arthritis in Rats Through Activating NLRP3 Inflammasome and Inflammatory Cytokine Production

Journal of Inflammation Research, 2022
Xiaojuan Dai,1,* Xuan Fang,1,* Yuan Xia,1 Manyun Li,1 Xiaomei Li,1 Yiping Wang,2 Jinhui Tao,1 Xiangpei Li1 1Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of ...
Dai X, Fang X, Xia Y, Li M, Li X, Wang Y, Tao J, Li X   +7 more
doaj  

The old and new concepts of acute gouty arthritis [PDF]

Arthritis & Rheumatism, 1962
CUTE GOUTY ARTHRITIS was regarded by Garrod in 1876 as an inA flammatory reaction to crystals of sodium urate that had been deposited in and about the joint. He further concluded that a local deposition of sodium urate occurred during the acute attack.l Much of his evidence for such a concept was tenuous by modern concepts and failure of investigators ...
J E, SEEGMILLER, R R, HOWELL
openaire   +2 more sources

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

Association between acute gouty arthritis and meteorological factors: An ecological study using a systematic review and meta-analysis

, 2017
OBJECTIVES: The aims of this study were as follows: (1) to analyze the literature systematically regarding the seasonal and monthly variation of the occurrence of episodes of acute gouty arthritis, and (2) to investigate the relationship between the ...
Kim, HJ, Park, KY, Ahn, HS, Jun, JB, Yim, SY   +4 more
core   +1 more source

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

Acute gouty arthritis without urate crystals identified on initial examination of synovial fluid [PDF]

, 1975
Nine patients who ultimately proved to have acute gouty arthritis did not have urate crystals demonstrable by compensated polarized light in the first joint fluid aspirated despite leukocyte counts as high as 100,000/mm3.
Pascual, Eliseo, Jimenez, Sergio A., Dorwart, Bonnie B., Gibson, Terry, Schumacher, H. Ralph, Traycof, Roger, Reginato, Antonio J.   +6 more
core   +1 more source

Changes of serum uric acid level during acute gout flare and related factors

Frontiers in Endocrinology, 2023
ObjectiveBy studying the changes of serum uric acid (SUA) in acute stage and remission stage of gouty arthritis, we aimed to explore the relationship between the changes of SUA level and free glucocorticoids and inflammatory factors.MethodsA prospective,
Jie Zhang, Jie Zhang, Wenyan Sun, Fei Gao, Jie Lu, Jie Lu, Jie Lu, Kelei Li, Yijun Xu, Yushuang Li, Changgui Li, Changgui Li, Changgui Li, Changgui Li, Ying Chen, Ying Chen   +15 more
doaj   +1 more source