Results 41 to 50 of about 6,617 (217)

Neutrophil extracellular trap clearance by synovial macrophages in gout

Arthritis Research & Therapy, 2021
Background Monosodium urate (MSU) crystals, i.e., the central etiological factors in gouty arthritis, induce the formation of neutrophil extracellular traps (NETs).
Ji Hye Jeong, Su Jin Choi, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong   +7 more
doaj   +1 more source

Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation

Medicina, 2021
Background and Objectives: Gouty arthritis is an acute inflammatory response caused by the precipitation of monosodium urate (MSU) crystals in joints. The triggering of MSU leads to increased production of inflammatory cytokines, such as interleukin-1β ...
Chih-Chien Wang, Jeng-Wei Lu, Yi-Jen Peng, Chian-Her Lee, Herng-Sheng Lee, You-Hsiang Chu, Chun-Jung Huang, Yi-Jung Ho, Feng-Cheng Liu, Chia-Chun Wu   +9 more
doaj   +1 more source

Musculoskeletal ultrasonography identifies structural damage in chronic kidney disease patients with gouty arthritis

Journal of Medical Sciences, 2023
Background: Renal insufficiency reduces the excretion of uric acid and inflammatory factors and exacerbates the structural deformities caused by gouty arthritis.
Zheng-Hao Huang, Tony Szu-Hsien Lee, Shu-Yi Lin, Ya-Chi Li, Fu-Chiang Yeh, Chun-Chi Lu   +5 more
doaj   +1 more source

Influence of intervention treatment by “heat-clearing and diuresis-promoting” prescription on NALP3, an inflammatory factor in acute gouty arthritis

Journal of Orthopaedic Surgery and Research, 2022
Background To investigate the efficacy of Qingre Lishi Decoction(QLRD), in the treatment of acute gouty arthritis, and its influence on the expression levels of inflammatory factor nucleotide-binding oligomerization domain-like receptor(NALP 3) in ...
Jun Yu, Lianrui Li, Jie Liu, Zhiyong Chen   +3 more
doaj   +1 more source

Acute gout – A harbinger for more serious outcome

APIK Journal of Internal Medicine, 2022
Gout is a crystal-induced arthropathy which can start as an acute arthritis and over a few years become chronic and cause systemic complications. Acute gout can manifest as an emergency and cause misery.
Manjunath Premanath
doaj   +1 more source

Suppressing chondrocyte cuproptosis by syringaresinol-4-O-β-d-glucoside alleviates gouty arthritis

Frontiers in Pharmacology
BackgroundGouty arthritis is a rheumatic disease characterized by synovial inflammation and cartilage damage. Current therapeutic options for gouty arthritis, such as colchicine, primarily relieve the symptoms, which makes treatment challenging.MethodsWe
Shaotian Fu, Han Du, Xiao Ling, Hanyi Wang, Jianan Chen, Hang Zhang, Wugui Chen, Chengzhao Liu, Hailong Ma, Chengshou Lin, Peixiang Ma, An Qin   +11 more
doaj   +1 more source

Effect of fenoprofen calcium on acute gouty arthritis [PDF]

Arthritis & Rheumatism, 1976
AbstractTwenty‐seven patients with thirty‐six joints affected with acute gouty arthritis were treated with fenoprofen calcium for a duration not exceeding 8 days and with a variable dose not exceeding 3.2 g daily. The results indicate that fenoprofen calcium was an effective drug in these patients. Side effects were modest.
S, Wanasukapunt, Y, Lertratanakul, H M, Rubinstein   +2 more
openaire   +2 more sources

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Role of Ultrasonography in Diagnosing Gouty Arthritis

, 2011
Urate crystal deposition in the joints is the hallmark of gout. The aim of our study is to determine the characteristic sonographic features of gouty arthritis, and to evaluate the utility of ultrasonography (US) in diagnosing gouty arthritis.
Chiu, Ying-Ming, Ying-Ming Chiu, Lai, Kuo-Lung, Kuo-Lung Lai   +3 more
core   +1 more source