Results 251 to 260 of about 677,866 (413)

Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome

open access: yesArthritis &Rheumatology, Accepted Article.
Background ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. Objective To evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired thrombo‐inflammatory ...
Bruna de Moraes Mazetto Fonseca   +13 more
wiley   +1 more source

CONGRESS COVERAGE: Antihypertensive Therapy in Acute Ischemic Stroke: Lost in the Mist [PDF]

open access: diamond, 2014
Κωνσταντίνος Τζιόμαλος   +2 more
openalex   +1 more source

An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon‐like peptide‐1 and glucagon receptor in healthy subjects

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Glucagon‐like peptide‐1 (GLP‐1) and glucagon dual receptor agonists are in clinical development for a range of metabolic conditions, including type 2 diabetes and obesity. The cardiovascular actions at these receptors are well studied, but less is known about their combination.
James Goodman   +13 more
wiley   +1 more source

Drip and ship in patients with acute ischemic stroke: a narrative review. [PDF]

open access: yesTher Adv Neurol Disord
Palaiodimou L   +15 more
europepmc   +1 more source

Time-Dependent Computed Tomographic Perfusion Thresholds for Patients With Acute Ischemic Stroke

open access: yesStroke, 2015
C. d'Esterre   +18 more
semanticscholar   +1 more source

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence for regulatory science and innovation in pharmacogenomics (CERSI‐PGx)

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and peripheral arterial disease. Clopidogrel requires metabolic activation by the cytochrome P450 enzyme CYP2C19 to be effective.
Cinzia Dello Russo   +22 more
wiley   +1 more source

Acute Ischemic Stroke Following a Camel Bite to the Neck: A Case Report. [PDF]

open access: yesCureus
Humaida AA   +4 more
europepmc   +1 more source

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