Results 51 to 60 of about 167,455 (238)

Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation

Advanced Sensor Research, EarlyView.
Magnetic particle spectroscopy and imaging represent promising tools, particularly when combined with manganese‐ferrite nanoparticles as versatile theranostic agents. Adjusting the manganese content allows for simultaneous multi‐color tracer detection and reactive oxygen species sensing via magnetic particle spectroscopy and imaging, creating new ...
Fabian H. L. Starsich, Julia Feye, Robert Niβler, Gabriela Da Silva André, Elena Totter, Konrad Scheffler, Florian Thieben, Erik Mayr, Jochen Franke, Tobias Knopp, Inge K. Herrmann   +10 more
wiley   +1 more source

HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke

Journal of Neuroinflammation, 2019
Introduction In humans, a major component of natural killer (NK) and T cell target recognition depends on the surveillance of human leukocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs).
Antonino Tuttolomondo, Domenico Di Raimondo, Rosaria Pecoraro, Alessandra Casuccio, Danilo Di Bona, Anna Aiello, Giulia Accardi, Valentina Arnao, Giuseppe Clemente, Vittoriano Della Corte, Carlo Maida, Irene Simonetta, Calogero Caruso, Rosario Squatrito, Antonio Pinto, on behalf of KIRIIND (KIR Infectious and Inflammatory Diseases) Collaborative Group   +15 more
doaj   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection

Journal of Blood Medicine, 2023
Lisda Amalia Department of Neurology, Medical Faculty, Universitas Padjadjaran, Bandung, IndonesiaCorrespondence: Lisda Amalia, Department of Neurology, Medical Faculty, Universitas Padjadjaran, Jl.
Amalia L
doaj  

A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

Advanced Science, EarlyView.
The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du, Muhammad Rafiq, Hui Yuan, Xiangmin Li, Sheng Wang, Jun Wu, Jinfeng Wei, Ren‐Ke Li, Huiming Guo, Burton B Yang   +9 more
wiley   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source

Comparison of Regional Lepomeningeal Collateral Score and Tan Collateral Score in prediction of prognosis of anterior ischemic stroke with intravenous thrombolysis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
Objective To screen the related influencing factors of prognosis in acute anterior ischemic stroke patients who underwent intravenous thrombolysis, and to explore the predictive ability of two collateral scores based on CT angiography (CTA).
Yan CHEN, Jia-ju ZHAO, Bo WU
doaj   +1 more source

Advancements in Bio‐Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare

Advanced Science, EarlyView.
This review explores the cutting‐edge development of bio‐integrated flexible electronics for real‐time hemodynamic monitoring in cardiovascular healthcare. It covers key physiological indicators, innovative sensing mechanisms, and materials considerations. This paper highlights the application of both invasive and non‐invasive devices in cardiovascular
Ke Huang, Zhiqiang Ma, Bee Luan Khoo
wiley   +1 more source