Results 51 to 60 of about 707,511 (342)

Cellular pathophysiology of ischemic acute kidney injury.

Journal of Clinical Investigation, 2011
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury ...
J. Bonventre, Li Yang
semanticscholar   +1 more source

Assessment of acute kidney injury risk using a machine-learning guided generalized structural equation model: a cohort study

BMC Nephrology, 2021
Background Acute kidney injury is common in the surgical intensive care unit (ICU). It is associated with poor patient outcomes and high healthcare resource usage. This study’s primary objective is to help identify which ICU patients are at high risk for
Wen En Joseph Wong, Siew Pang Chan, Juin Keith Yong, Yen Yu Sherlyn Tham, Jie Rui Gerald Lim, Ming Ann Sim, Chai Rick Soh, Lian Kah Ti, Tsong Huey Sophia Chew   +8 more
doaj   +1 more source

Roles of DNA damage in renal tubular epithelial cells injury

Frontiers in Physiology, 2023
The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking.
Peipei Wang, Peipei Wang, Peipei Wang, Jing Ouyang, Jing Ouyang, Jing Ouyang, Zhanjun Jia, Zhanjun Jia, Zhanjun Jia, Aihua Zhang, Aihua Zhang, Aihua Zhang, Yunwen Yang, Yunwen Yang, Yunwen Yang   +14 more
doaj   +1 more source

Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

Nature Communications, 2021
Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It is correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS).
Qinjie Weng, Heng Sun, Chunyan Fang, Fan Xia, Hongwei Liao, Jiyoung Lee, Jincheng Wang, An Xie, Jiafeng Ren, Xia Guo, Fangyuan Li, Bo Yang, D. Ling   +12 more
semanticscholar   +1 more source

Heart failure subtype after acute kidney injury

BMC Nephrology
Introduction Acute kidney injury (AKI) is associated with increased risk of heart failure (HF). Determining the type of HF experienced by AKI survivors (heart failure with preserved or reduced ejection fraction, HFpEF or HFrEF) could suggest potential ...
Bethany C. Birkelo, Evan Brittain, Andrew Guide, Robert A. Greevy, Michael E. Matheny, Jeffrey Annis, Trey Richardson, Sarah Faubel, Edward D. Siew   +8 more
doaj   +1 more source

Immune Checkpoint Inhibitors and Kidney Toxicity: Advances in Diagnosis and Management

Kidney Medicine, 2021
Immune checkpoint inhibitors are now approved for more than 50 indications, and increasing numbers of patients with advanced cancer are receiving immunotherapy.
Harish Seethapathy, Sandra M. Herrmann, Meghan E. Sise   +2 more
doaj  

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Nature Communications, 2021
Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (ATN).
W. Tonnus, C. Meyer, C. Steinebach, A. Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, F. Maremonti, F. Gembardt, N. Himmerkus, Markus Latk, S. Locke, J. Marschner, Wenjun Li, S. Short, S. Doll, Irina Ingold, B. Proneth, C. Daniel, Nazanin Kabgani, R. Kramann, Stephen E. Motika, P. Hergenrother, S. Bornstein, C. Hugo, J. Becker, K. Amann, H. Anders, D. Kreisel, D. Pratt, M. Gütschow, M. Conrad, A. Linkermann   +31 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.

New England Journal of Medicine, 2020
Background Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for the initiation of such therapy remains uncertain. Methods We conducted a multinational, randomized,
Starrt-Aki Investigators, S. Bagshaw, R. Wald, N. Adhikari, R. Bellomo, Bruno R. da Costa, D. Dreyfuss, Bin Du, M. Gallagher, S. Gaudry, E. Hoste, F. Lamontagne, M. Joannidis, G. Landoni, Kathleen D. Liu, D. McAuley, S. McGuinness, Javier A. Neyra, A. Nichol, M. Ostermann, P. Palevsky, V. Pettilä, J. Quenot, H. Qiu, B. Rochwerg, Antoine G. Schneider, Orla M. Smith, Fernando Thomé, Kevin E Thorpe, S. Vaara, Matthew Weir, Amanda Y. Wang, Paul J Young, Alexander Zarbock   +33 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source