Results 61 to 70 of about 601,423 (296)

Clinical and Laboratory Characteristics of Acute Kidney Injury in Critically Ill Children: A Single Center Study [PDF]

Journal of Pediatrics Review, 2023
Background: Acute kidney injury stands out as one of the common complications in the pediatric intensive care unit.  Objectives: This study was designed to evaluate acute kidney injury’s frequency, etiologies, and its course in critically ill children ...
Faeghe Baryar Langroudi, Hamid Mohammadjafari, Hani Rostami Rad, Mohaddeseh Momeni, Maedeh Guran, Mohammad Reza Navaeifar   +5 more
doaj  

Impact of acute kidney injury on major adverse cardiovascular events in intensive care survivors

BJA Open, 2023
Background: Acute kidney injury commonly occurs in patients admitted to ICU. After acute kidney injury, kidney function may not completely recover leading to increased risk of future cardiovascular events.
Mark Andonovic, Jennifer Curle, Jamie P. Traynor, Martin Shaw, Malcolm A.B. Sim, Patrick B. Mark, Kathryn A. Puxty   +6 more
doaj   +1 more source

A comparison of the effects of oral vs. intravenous hydration on subclinical acute kidney injury: a protocol of a randomised controlled trial [PDF]

, 2017
Background: Optimal treatment for established renal failure is living donor kidney transplantation. However this pathway exposes healthy individuals to significant reduction in nephron mass via major surgical procedure.
Aitken, Emma, Clancy, Marc, Ghita, Ryan, Mackinnon, Shona   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study [PDF]

, 2008
Introduction: The purpose of this study was to determine the incidence, time course, and outcome of acute kidney injury after major burns and to evaluate the impact of possible predisposing factors ( age, gender, and depth and extent of injury) and the ...
F Sjoberg, I Steinvall, Z Bak
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

The Aging Kidney: Increased Susceptibility to Nephrotoxicity [PDF]

, 2014
Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury.
Bonventre, Joseph V., Parrish, Alan R., Wang, Xinhui   +2 more
core   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Do acute elevations of serum creatinine in primary care engender an increased mortality risk? [PDF]

, 2014
Background: The significant impact Acute Kidney Injury (AKI) has on patient morbidity and mortality emphasizes the need for early recognition and effective treatment.
A Bottle, A Lassnigg, A Wonnacott, AS Levey, B Talabani, Christopher KT Farmer, CY Hsu, Department of Health, EA Hoste, EM Burns, GM Chertow, Helen Hobbs, J Stewart, Jean Irving, JP Lafrance, L Gruberg, M Bedford, M Bedford, Michael Bedford, ML Praught, MM Levy, MM Schissler, Office of National Statistics, PA McCullough, Paul Bassett, Paul E Stevens, PG Metnitz, PK Li, R Bellomo, R Mehta, RL Mehta, RL Mehta, RW Schrier, S Uchino, SS Waikar, Toby Wheeler   +35 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source