Results 51 to 60 of about 400,419 (299)

Clinical and Laboratory Characteristics of Acute Kidney Injury in Critically Ill Children: A Single Center Study [PDF]

Journal of Pediatrics Review, 2023
Background: Acute kidney injury stands out as one of the common complications in the pediatric intensive care unit.  Objectives: This study was designed to evaluate acute kidney injury’s frequency, etiologies, and its course in critically ill children ...
Faeghe Baryar Langroudi, Hamid Mohammadjafari, Hani Rostami Rad, Mohaddeseh Momeni, Maedeh Guran, Mohammad Reza Navaeifar   +5 more
doaj  

Acute kidney injury model established by systemic glutathione depletion in mice [PDF]

, 2019
Glutathione (GSH) is one of the most extensively studied tripeptides. The roles for GSH in redox signaling, detoxification of xenobiotics and antioxidant defense have been investigated.
Yokoi, Tsuyoshi, Matsubara, Akiko, Akiko Matsubara, Ru Jia, Tsuyoshi Yokoi, Shingo Oda, Oda, Shingo, Jia, Ru   +7 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Assessment of acute kidney injury risk using a machine-learning guided generalized structural equation model: a cohort study

BMC Nephrology, 2021
Background Acute kidney injury is common in the surgical intensive care unit (ICU). It is associated with poor patient outcomes and high healthcare resource usage. This study’s primary objective is to help identify which ICU patients are at high risk for
Wen En Joseph Wong, Siew Pang Chan, Juin Keith Yong, Yen Yu Sherlyn Tham, Jie Rui Gerald Lim, Ming Ann Sim, Chai Rick Soh, Lian Kah Ti, Tsong Huey Sophia Chew   +8 more
doaj   +1 more source

Biomarkers in Acute Kidney Injury [PDF]

Biomarker Insights, 2008
Acute Renal Failure (ARF) remains a common and significant problem in modern medicine. The epidemiology and causes of ARF vary according to the clinical setting; in intensive care units it is estimated that the incidence of ARF ranges from 10%–25%,1,2 with acute tubular necrosis (ATN) accounting for about 75% of cases.3 Recent data from the BEST ...
Martine Leblanc, Jean-François Naud
openaire   +4 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Impact of acute kidney injury on major adverse cardiovascular events in intensive care survivors

BJA Open, 2023
Background: Acute kidney injury commonly occurs in patients admitted to ICU. After acute kidney injury, kidney function may not completely recover leading to increased risk of future cardiovascular events.
Mark Andonovic, Jennifer Curle, Jamie P. Traynor, Martin Shaw, Malcolm A.B. Sim, Patrick B. Mark, Kathryn A. Puxty   +6 more
doaj   +1 more source

Estimated glomerular filtration rate correlates poorly with four-hour creatinine clearance in critically ill patients with acute kidney injury.

, 2013
Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is
Iain A. M. MacPhee, Kirwan, CJ, Barbara J. Philips, Christopher J. Kirwan, Philips, BJ, Macphee, IA   +5 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source