Results 51 to 60 of about 1,570,861 (237)

Characterisation of cells markers associated with IKZF1plus in BCP-ALL

Translational Oncology
The presence of IKZF1 deletions has been associated with an increased relapse rate in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). There is a particular subset of IKZF1del cases called IKZF1plus (defined by the co-occurrence of IKZF1del and ...
Caroline Barbieri Blunck, Caroline Pires Poubel, Bruno A. Lopes, Thayana C. Barbosa, Ana Luiza Tardem Maciel, Elaine Sobral da Costa, Ariadne da Rocha Figueiredo, Marcelo G.P. Land, Márcia Trindade Schramm, Maura Rosane Valério Ikoma-Coltutato, Renan Garcia Gomes, Mecneide Mendes Lins, Thais Ferraz Aguiar, Marcela Braga Mansur, Mariana Emerenciano   +14 more
doaj   +1 more source

Acute B lymphoblastic leukaemia‐propagating cells are present at high frequency in diverse lymphoblast populations

EMBO Molecular Medicine, 2012
Leukaemia‐propagating cells are more frequent in high‐risk acute B lymphoblastic leukaemia than in many malignancies that follow a hierarchical cancer stem cell model.
Klaus Rehe, Kerrie Wilson, Simon Bomken, Daniel Williamson, Julie Irving, Monique L. den Boer, Martin Stanulla, Martin Schrappe, Andrew G. Hall, Olaf Heidenreich, Josef Vormoor   +10 more
doaj   +1 more source

Acute leukaemoid reaction following cardiac surgery

Journal of Cardiothoracic Surgery, 2007
Chronic myelomonocytic leukaemia is an atypical myeloproliferative disorder with a natural history of progression to acute myeloid leukaemia, a complex and poorly understood response by the bone marrow to stress.
Webb Stephen T, Mussa Shafi, Ali Ayyaz, Drury Nigel E, Rege Kanchan P, Wallwork John   +5 more
doaj   +1 more source

Investigations of FLT3 internal tandem duplications in patients with acute myeloid leukaemia. [PDF]

, 2006
In acute myeloid leukaemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated an internal tandem duplication (ITD) in the FLT3 gene may adversely
Kottaridis, P.D., Kottaridis, Panagiotis
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluation of the cytogenetic profile in patients with acute leukaemia

, 2023
Acute leukaemia (AL) is a heterogeneous neoplastic disease that occurs by the growth of abnormal lymphoid and myeloid cells in the bone marrow and blood leading to acute myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).
Akanksha A Kalal, Meenakshi Arumugam, Nagaraj V Kulkarni, Vijith V Shetty, Rajesh Krishna, Reshma A Shetty, Kishan Prasad HL, D. Prashanth Shetty   +7 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Paediatric Acute Leukaemia: Management in the Era of Precision Medicine and Immunotherapy

Apollo Medicine
Background: Acute leukaemia is the most common childhood malignancy, comprising predominantly acute lymphoblastic leukaemia (ALL) and, less frequently, acute myeloid leukaemia (AML).
Minakshi Bansal, Amita Mahajan
doaj   +1 more source