Results 171 to 180 of about 742,291 (311)

Asciminib for relapsed or refractory Philadelphia chromosome–positive acute lymphoblastic leukemia

Blood Advances
Mathilde Chanut, Aurélie Cabannes-Hamy, Marie Balsat, Nassim Sahki, Emmanuel Raffoux, Yosr Hicheri, Bruno Lioure, Lucie Laemmel, Thibaut Leguay, Victoria Cacheux, Maria Pilar Gallego-Hernanz, Andrea Pieragostini, Gabrielle Roth-Guepin, Ludovic Gabellier, Nathalie Denizon, Lise Willems, Quentin Cabrera, Sylvain Chantepie, Valérie Coiteux, Claudie Capdupuy, Martin Carré, Antoine Machet, Juliette Lambert, Sandrine Roux, Franck-Emmanuel Nicolini, Nicolas Boissel, Emmanuelle Clappier, Rathana Kim, Philippe Rousselot   +28 more
doaj   +1 more source

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia [PDF]

, 2020
Shinobu Tsuzuki, Takahiko Yasuda, Shinya Kojima, Masahito Kawazu, Koshi Akahane, Takeshi Inukai, Masue Imaizumi, Takanobu Morishita, Koichi Miyamura, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Toshinori Hyodo, Hiroyuki Konishi, Masashi Sanada, Hirokazu Nagai, Keizo Horibe, Akihiro Tomita, Kyogo Suzuki, Hideki Muramatsu, Yoshiyuki Takahashi, Yasushi Miyazaki, Itaru Matsumura, Hitoshi Kiyoi, Yoshitaka Hosokawa, Hiroyuki Mano, Fumihiko Hayakawa   +26 more
openalex   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Sorafenib improves survival of FLT3-mutated acute myeloid leukemia in relapse after allogeneic stem cell transplantation: a report of the EBMT Acute Leukemia Working Party

Haematologica, 2019
Ali Bazarbachi, Myriam Labopin, Giorgia Battipaglia, Azedine Djabali, Jakob Passweg, Gerard Socié, Edouard Forcade, Didier Blaise, Patrice Chevallier, Corentin Orvain, Jan J. Cornelissen, William Arcese, Sylvain Chantepie, Khowla Hashaishi, Jean El Cheikh, Michael Medinger, Jordi Esteve, Arnon Nagler, Mohamad Mohty   +18 more
doaj   +1 more source

Rapid epigenomic classification of acute leukemia. [PDF]

Nat Genet
Steinicke TL, Benfatto S, Capilla-Guerra MR, Monteleone AB, Young JH, Shankar S, Michaels PD, Tsai HK, Good JD, Kreso A, van Galen P, Schliemann C, Chen EC, Griffin GK, Hovestadt V.   +14 more
europepmc   +1 more source

Simultaneous appearance of dual malignancies of hematopoietic system-multiple myeloma and acute myeloid leukemia

, 2008
Jyoti Shukla, Shashikant Patne, Singh Nk, Usha Panihar   +3 more
openalex   +1 more source

Allogeneic Hematopoietic Stem Cell Transplantation for Children and Adolescents with Acute Myeloid Leukemia in Brazil: A Multicentric Retrospective Study [PDF]

, 2020
Ana Luiza Rodrigues, Carmem Bonfim, Adriana Seber, Vergílio Antônio Rensi Colturato, Victor Gottardello Zecchin, Samantha Nichele, Liane Esteves Daudt, Juliana Folloni Fernandes, Ana Karine Vieira, Luiz Guilherme Darrigo, Alessandra Araújo Gomes, Leonardo Javier Arcuri, Luana Lenzi, Gledson Luiz Picharski, Raul C. Ribeiro, Bonald C. Figueiredo   +15 more
openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Clinical Outcomes of Adult Patients With Newly Diagnosed Mixed Phenotype Acute Leukemia. [PDF]

JCO Precis Oncol
Goulart H, Ravandi F, Short NJ, Jain N, Daver N, Kadia TM, DiNardo C, Borthakur G, Takahashi K, Pemmaraju N, Haddad FG, Montalban Bravo G, Alvarado Y, Issa GC, Bataller A, Pierce S, Loghavi S, Tang G, Wang SA, Thakral B, Shpall E, Champlin R, Khouri I, Kebriaei P, Garcia-Manero G, Sasaki K, Jabbour EJ, Senapati J.   +27 more
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source