Results 61 to 70 of about 386,804 (284)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Prognostic markers in acute liver failure - Alpha feto protein

Archives of Medicine and Health Sciences, 2021
Background and Aim: Acute liver failure is associated with high mortality and only about 40% patients survive without liver transplantation. The available prognostic models failed to predict the outcome correctly.
P Gayathri, Smitha Krishnamoorthy, Subhash Chandra, M G K Pillai, Raviraj Menon, Mahesh Subramania Iyer   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Liver transplantation for late-onset presentations of acute liver failure in Wilson's disease: The UK experience over 2 decades

JHEP Reports, 2020
Background & Aims: Acute liver failure as the initial presentation of Wilson’s disease is usually associated with onset in childhood, adolescence or early adulthood.
Samuel Shribman, Gwilym Webb, Rhiannon Taylor, Thomas T. Warner, Adam Duckworth, Alexander Gimson, Achuth Shenoy, William Griffiths   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Case Report: Acute-on-Chronic Liver Failure: Making the Diagnosis between Infection and Acute Alcoholic Hepatitis [PDF]

, 2016
Acute-on-chronic liver failure (ACLF) represents a reversible syndrome associated with high short-term mortality, characterized by acute decompensation in patients with chronic liver disease and extrahepatic organ failure.
Sousa, José Manuel, Ampuero Herrojo, Javier, Giráldez Gallego, Álvaro, Romero Gómez, Manuel, Sendra, Carmen   +4 more
core   +1 more source

Systematic review of the global epidemiology of viral-induced acute liver failure

BMJ Open, 2020
Objectives The aetiology and burden of viral-induced acute liver failure remains unclear globally. It is important to understand the epidemiology of viral-induced ALF to plan for clinical case management and case prevention.Participants This systematic ...
Rudzani Muloiwa, Jenna Patterson, Hannah Sophia Hussey, Sheetal Silal, Liz Goddard, Mashiko Setshedi, Wendy Spearman, Gregory D Hussey, Benjamin M Kagina   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats [PDF]

, 2012
Acute ethanol intoxication increases the production of reactive oxygen species (ROS). Hemorrhagic shock with subsequent resuscitation (H/R) also induces ROS resulting in cellular and hepatic damage in vivo.
Henrich, Dirk, Marzi, Ingo, Lehnert, Mark, Wilhelm, Kerstin, Wang, Minhong, Relja, Borna   +5 more
core   +1 more source

Liver Transplantation because of Acute Liver Failure due to Heme Arginate Overdose in a Patient with Acute Intermittent Porphyria

Case Reports in Gastroenterology, 2012
In acute attacks of acute intermittent porphyria, the mainstay of treatment is glucose and heme arginate administration. We present the case of a 58-year-old patient with acute liver failure requiring urgent liver transplantation after erroneous 6-fold ...
Pascal Frei, Elisabeth I. Minder, Natascia Corti, Beat Muellhaupt, Andreas Geier, Heiner Adams, Jean-Paul Dutertre, Alain Rudiger, Philipp Dutkowski, Marco Maggiorini, Christoph C. Ganter   +10 more
doaj   +1 more source