Results 51 to 60 of about 542,420 (309)

A fresh look at paralytics in the critically ill: real promise and real concern. [PDF]

, 2012
Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails.
Kenyon, Nicholas J, Price, David, Stollenwerk, Nicholas   +2 more
core   +2 more sources

AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of VE-Cadherin

Mediators of Inflammation, 2017
Maintenance of pulmonary endothelial barrier integrity is important for reducing severity of lung injury. Lysophosphatidic acid (LPA) regulates cell motility, cytoskeletal rearrangement, and cell growth.
Junting Cai, Jianxin Wei, Shuang Li, Tomeka Suber, Jing Zhao   +4 more
doaj   +1 more source

A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

Nature Communications, 2021
The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen, Travis B. Lear, John W. Evankovich, Mads B. Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Laura Salminen, Daniel P. Camarco, Karina C. Lockwood, Ferhan Tuncer, Jie Liu, Michael M. Myerburg, John F. McDyer, Yuan Liu, Toren Finkel, Bill B. Chen   +16 more
doaj   +1 more source

Physiological effects of high-flow oxygen via endotracheal tube versus T-piece strategies during spontaneous breathing trials: a study protocol and statistical analysis for a single-centre randomised crossover study

BMJ Open
Introduction The optimal method for conducting spontaneous breathing trials (SBTs) remains a subject of ongoing debate. High-flow oxygen via endotracheal tube (HFOT) has emerged as a novel alternative for SBTs.
Jian-Xin Zhou, Hong-Liang Li, Ming-Yue Miao, Shan-Shan Xu, Rui-Zhi Zhang, Xu An, Yue-Fu Wang   +6 more
doaj   +1 more source

Translational medicine for acute lung injury

Journal of Translational Medicine
Acute lung injury (ALI) is a complex disease with numerous causes. This review begins with a discussion of disease development from direct or indirect pulmonary insults, as well as varied pathogenesis.
Jianguo Zhang, Yumeng Guo, Michael Mak, Zhimin Tao   +3 more
semanticscholar   +1 more source

Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

Inflammation Research, 2020
Macrophages are highly plastic cells. Under different stimuli, macrophages can be polarized into several different subsets. Two main macrophage subsets have been suggested: classically activated or inflammatory (M1) macrophages and alternatively ...
Xuxin Chen, Jian Tang, Wei-zheng Shuai, Jiguang Meng, Jian Feng, Zhihai Han   +5 more
semanticscholar   +1 more source

ICOS-Expressing Lymphocytes Promote Resolution of CD8-Mediated Lung Injury in a Mouse Model of Lung Rejection [PDF]

, 2014
Acute rejection, a common complication of lung transplantation, may promote obliterative bronchiolitis leading to graft failure in lung transplant recipients.
Berry, Elizabeth, Cannon, Judy L., Clay, Bryan S., Ferreira, Caroline M., Gardiner, Gail J., Lu, Tiffany, Luster, Andrew D., Medoff, Benjamin D., Moore, Tamson V., Shilling, Rebecca A., Sperling, Anne I., Wagner, Sarah R., Williams, Jesse W., Wu, Qiang   +13 more
core   +1 more source

Transfusion-related acute lung injury [PDF]

, 2007
Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasma-containing blood components. Recently, TRALI has come to be recognized as the leading cause of transfusion-related death in the United ...
Bordin, Jose Orlando, Fabron Junior, Antonio, Lopes, Larissa Barbosa   +2 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Silencing airway epithelial cell-derived hepcidin exacerbates sepsis-induced acute lung injury [PDF]

, 2014
INTRODUCTION: The production of antimicrobial peptides by airway epithelial cells is an important component of the innate immune response to pulmonary infection and inflammation. Hepcidin is a β-defensin-like antimicrobial peptide and acts as a principal
Cong Li Zeng, Jun Lu Wang, Qi Xing Chen, Qing Hua Chen, Sheng Wen Song, Xia Zheng, Xiang Ming Fang   +6 more
core   +1 more source