Results 141 to 150 of about 6,391 (198)

Clinical significance and immune microenvironment association of cuproptosis‐related genes in pan‐cancer

Experimental Physiology, EarlyView.
Abstract Recent studies highlight the important roles of cuproptosis in cancer cells. However, the roles of the cuproptosis‐related genes (CRGs) in different cancers are still not fully understood. Comprehensive analysis was performed using open‐source bioinformatic platforms to disclose the expression profiles, prognostic significance, genomic and ...
Xinyu Ge, Kaijing Wang, Tian Zhao, Jinyi Wang, Jie Liu, Zhengliang Sun, Zhengjun Chai, Wen Zhang, Chengbao Li, Yan Xu, Guohan Chen   +10 more
wiley   +1 more source

Cancer treatment and survivorship statistics, 2025

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The number of people living with a history of cancer in the United States continues to rise because of the growth and aging of the population as well as improved survival through advances in early detection and treatment. To assist the public health community serve the needs of these survivors, the American Cancer Society and the National ...
Nikita Sandeep Wagle, Leticia Nogueira, Theresa P. Devasia, Angela B. Mariotto, K. Robin Yabroff, Farhad Islami, Ahmedin Jemal, Rick Alteri, Patricia A. Ganz, Rebecca L. Siegel   +9 more
wiley   +1 more source

GREM1 deficiency induced bone marrow adipose niche promotes B‐cell acute lymphoblastic leukemia disease progression

International Journal of Cancer, Volume 157, Issue 3, Page 559-572, 1 August 2025.
What's new? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song, Rui Zhang, Liya Pan, Qiang Mi, Yi Yang, Xiang Wang, Yani Ma, Shuhong Shen, Benshang Li, Yanxin Li, Li Hong   +10 more
wiley   +1 more source

Human‐Centered Design of a Personalized Digital Health Intervention to Improve Oral Chemotherapy Adherence in Adolescents and Young Adults With Hematologic Cancers

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Background Acute lymphoblastic leukemia/lymphoma therapy includes a maintenance phase involving daily administration of an oral chemotherapy called 6‐mercaptopurine (6‐MP). Adolescents and young adults (AYAs) exhibit lower 6‐MP adherence than younger patients, which increases their relapse risk.
Alexandra M. Psihogios, Ayah El‐Khatib, Kevin Matos, Mashfiqui Rabbi, Jenna Rossoff, Shira Dinner, Kristy Zeng, Raymundo Picos, Annisa Ahmed, Esha M. Patel, Linda Fleisher, Stephen P. Hunger, Ahna Pai, Jean‐Philippe Laurenceau, Christine Rini, Lamia P. Barakat, Lisa A. Schwartz, Susan Murphy, Betina Yanez   +18 more
wiley   +1 more source

Whole Abdominal Radiotherapy Is Tolerable and Effective in Children and Young Adults With Intra‐Abdominal Sarcoma: A Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) Study

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Background Whole abdominal radiotherapy (WART) is utilized in children, adolescents, and young adults with intra‐abdominal sarcoma, but efficacy and toxicity are uncertain. Methods Sarcoma patients diagnosed at ≤39 years of age between 1998 and 2023 who received WART were identified from a national registry.
Rebecca J. Deyell, Hagit Peretz Soroka, Delaney Sharp, Caroline Ruus, Jeffrey N. Bone, Mai‐Kim Gervais, Audrey Roux, Xiaolan Feng, Natalie Logie, Nicolas Prudhomme, Caroline Holloway, Abha A. Gupta, Derek S. Tsang   +12 more
wiley   +1 more source

Prediction of B/T Subtype and ETV6–RUNX1 Translocation in Pediatric Acute Lymphoblastic Leukemia by Deep Learning Analysis of Giemsa‐Stained Whole Slide Images of Bone Marrow Aspirates

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Background Accurate determination of B/T‐cell lineage and the presence of the ETV6–RUNX1 translocation is critical for diagnosing acute lymphoblastic leukemia (ALL), as these factors influence treatment decisions and outcomes. However, these diagnostic processes often rely on advanced tools unavailable in low‐resource settings, creating a need
Arkadi Piven, Gil Shamai, Sarah Elitzur, Galit Pinto Berger, Yoav Binenbaum, Ron Kimmel, Ronit Elhasid   +6 more
wiley   +1 more source

How I Approach Ethical Considerations for Pediatric Phase I CAR T‐Cell Trials

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Phase I trials of chimeric antigen receptor (CAR) T cells have shown remarkable promise in pediatric B‐cell malignancies. Such outcomes have shifted expectations for other phase I CAR T‐cell trials to have high response rates. The juxtaposition of high expectations, uncertain outcomes, and potential for life‐threatening toxicities raises ...
Sarah W. Peters, Sara K. Silbert, Elizabeth M. Holland, Annette Rid, Rayne H. Rouce, Christine Grady, Nirali N. Shah   +6 more
wiley   +1 more source

Long‐Term Projections of Childhood Cancer Incidence and Prevalence in Ontario, Canada Until 2040

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Background The prevalence of childhood cancer continues to rise due to increases in cancer incidence and advances in treatment, leading to better survival. We generated epidemiologic projections for childhood cancer, by cancer type, in Ontario, Canada, until 2040.
Alexandra Moskalewicz, Sumit Gupta, Petros Pechlivanoglou, Paul C. Nathan   +3 more
wiley   +1 more source

Infectious Morbidity During Pediatric Acute Myeloid Leukemia Chemotherapy in a High‐Income Country: A 15‐Year Population‐Based Overview

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Introduction Infection causes significant morbidity and mortality in pediatric acute myeloid leukemia (pAML). This study describes the incidence and risk factors of bloodstream infection (BSI) and invasive fungal infection (IFI) in pAML. Methods A retrospective chart review was performed of patients treated according to the ANLL‐97/AML‐12 (N =
Emily R. Schwartz, Kim Klein, Birgit I. Lissenberg‐Witte, Tom F. W. Wolfs, Valérie de Haas, Bianca Goemans, Natasja Dors, Marry M. van den Heuvel‐Eibrink, Rutger R. G. Knops, Wim J. E. Tissing, Birgitta A. Versluys, C. Michel Zwaan, Raphaële R. L. van Litsenburg, Gertjan J. L. Kaspers   +13 more
wiley   +1 more source

Effects of a Low Versus Moderate–High Intense Exercise Program on Innate Immune Recovery, Fitness, and Quality of Life During Pediatric Allo‐HSCT—The ANIMAL Exploratory Randomized Controlled Trial

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT Objectives Pediatric cancer patients undergoing allogeneic hematopoietic stem cell transplantation (allo‐HSCT) are severely immunosuppressed leading to a high risk for life‐threatening infections. This trial investigates the effects of exercise during allo‐HSCT on immune cell recovery and patient‐related outcomes (DRKS00019865). Methods Twenty‐
Ronja Beller, Sabrina B. Bennstein, Dirk Reinhardt, Gabriele Gauß, Carolina Chamorra Vina, Helmut Hanenberg, Markus Uhrberg, Miriam Götte   +7 more
wiley   +1 more source