Acute lymphoblastic leukemia - Open Access .click

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MMIL: A novel algorithm for disease associated cell type discovery [PDF]

arXiv
Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization method that enables the training and calibration of cell-level classifiers using patient-level labels. Our approach can
arxiv

Philadelphia chromosome positive childhood acute lymphoblastic leukemia [PDF]

, 1980
JR Priest +9 more
openalex +3 more sources

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

Science Translational Medicine, 2013
R. Brentjens +24 more
semanticscholar +1 more source

New approaches to the management of adult acute lymphoblastic leukemia [PDF]

Traditional treatment regimens for adult acute lymphoblastic leukemia, including allogeneic hematopoietic cell transplantation, result in an overall survival of about 40%, a figure hardly comparable with the extraordinary 80-90% cure rate currently ...
Bassan, R +3 more
core

Understanding the role of B-cells in CAR T-cell therapy in leukemia through a mathematical model [PDF]

arXiv
Chimeric Antigen Receptor T (CAR-T) cell therapy has been proven to be successful against different leukaemias and lymphomas. This paper makes an analytical and numerical study of a mathematical model describing the competition of CAR-T, leukaemias tumor and B cells.
arxiv

Autologous bone marrow transplantation for patients with acute lymphoblastic leukemia in second or subsequent remission: results of bone marrow treated with monoclonal antibodies BA-1, BA-2, and BA-3 plus complement [PDF]