Results 271 to 280 of about 401,465 (309)
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Pediatric Clinics of North America, 1997
Advances in the molecular and immunologic characterization of leukemic cells have greatly aided the diagnosis and risk assignment of ALL, as well as the monitoring of bone marrow samples for minimal residual disease. Currently, 75% of childhood cases have biologically and therapeutically relevant genetic abnormalities.
Pallavi M Pillai, William L. Carroll
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Advances in the molecular and immunologic characterization of leukemic cells have greatly aided the diagnosis and risk assignment of ALL, as well as the monitoring of bone marrow samples for minimal residual disease. Currently, 75% of childhood cases have biologically and therapeutically relevant genetic abnormalities.
Pallavi M Pillai, William L. Carroll
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Hematology, 2002
AbstractThis is a comprehensive overview on the most recent developments in diagnosis and treatment of acute lymphoblastic leukemia (ALL).Dr. Dieter Hoelzer and colleagues give an overview of current chemotherapy approaches, prognostic factors, risk stratification, and new treatment options such as tyrosine kinase inhibitors and monoclonal antibodies ...
Dieter, Hoelzer +7 more
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AbstractThis is a comprehensive overview on the most recent developments in diagnosis and treatment of acute lymphoblastic leukemia (ALL).Dr. Dieter Hoelzer and colleagues give an overview of current chemotherapy approaches, prognostic factors, risk stratification, and new treatment options such as tyrosine kinase inhibitors and monoclonal antibodies ...
Dieter, Hoelzer +7 more
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Clinics in Laboratory Medicine, 2000
Over the last two decades, great strides have been made in the treatment of acute lymphoblastic leukemia (ALL). This progress has been paralleled by advances in diagnosis. In addition to morphology and cytochemistry, the diagnostic and prognostic importance of immunophenotypic and genetic features is becoming increasingly apparent. This article reviews
D C, Farhi, N S, Rosenthal
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Over the last two decades, great strides have been made in the treatment of acute lymphoblastic leukemia (ALL). This progress has been paralleled by advances in diagnosis. In addition to morphology and cytochemistry, the diagnostic and prognostic importance of immunophenotypic and genetic features is becoming increasingly apparent. This article reviews
D C, Farhi, N S, Rosenthal
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2007
Acute lymphoblastic leukemia (ALL) comprises a heterogeneous group of disorders which originate from various important genetic lesions in B and T progenitor cells, including mutations that lead to stage-specific developmental arrest and those that impart the capacity for unlimited self-renewal, resulting in clonal expansion of immature progenitor cells
Biondi A., Scrideli C. A., Cazzaniga G.
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Acute lymphoblastic leukemia (ALL) comprises a heterogeneous group of disorders which originate from various important genetic lesions in B and T progenitor cells, including mutations that lead to stage-specific developmental arrest and those that impart the capacity for unlimited self-renewal, resulting in clonal expansion of immature progenitor cells
Biondi A., Scrideli C. A., Cazzaniga G.
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Clinics in Laboratory Medicine, 1999
This article reviews the laboratory methodologies used to evaluate acute lymphoblastic leukemia (ALL) in children and their role in establishing a diagnosis and prognosis of this disease. These methodologies are: morphology, flow cytometry, cytogenetics, and molecular diagnostics.
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This article reviews the laboratory methodologies used to evaluate acute lymphoblastic leukemia (ALL) in children and their role in establishing a diagnosis and prognosis of this disease. These methodologies are: morphology, flow cytometry, cytogenetics, and molecular diagnostics.
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Granular Acute Lymphoblastic Leukemia
American Journal of Clinical Pathology, 1983Granules in blasts are most typical of acute myeloblastic leukemia. However, there have been scattered reports of patients with acute lymphoblastic leukemia (ALL) that have lymphoblasts with azurophilic cytoplasmic granules. These reports do not describe immunologic markers or cytogenetics.
Debra Butler +5 more
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Pathobiology of acute lymphoblastic leukemia
Seminars in Diagnostic Pathology, 2011In the present review, the authors described the pathobiological features of B- and T-ALL, which appear to be quite heterogeneous with regard to molecular pathogenesis. The last edition of the World Health Organization Classification considered this aspect by defining many entities based on genetic findings.
PAOLINI, STEFANIA +5 more
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Pediatric Clinics of North America, 1980
The improved outlook in childhood leukemia can be attributed to more accurate diagnosis, better supportive care, the use of drug combinations to achieve and maintain remission, and prophylactic therapy to prevent central nervous system leukemia. With the best treatment available today, 65 to 70 per cent of children are in complete continuous remission ...
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The improved outlook in childhood leukemia can be attributed to more accurate diagnosis, better supportive care, the use of drug combinations to achieve and maintain remission, and prophylactic therapy to prevent central nervous system leukemia. With the best treatment available today, 65 to 70 per cent of children are in complete continuous remission ...
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Leukemia cutis in acute lymphoblastic leukemia
Journal of the American Academy of Dermatology, 1994separating normal epidermis from a diffuse dermal infiltrate of lymphoid blast cells with round and regular nuclei, inconspicuous nucleoli, and scanty, moderately basophilic cytoplasm. Immunophenotype analysis revealed strong positivity for CD 10.The patient wastreated with methotrexate, teniposide, cytosine arabinoside, and local irradiation, and a ...
J.M. Forjaz de Lacerda +5 more
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Treatment of Acute Lymphoblastic Leukemia
Annual Review of Medicine, 1972The treatment of acute lymphoblastic leukemia in the last decade can be said to have reached a revolutionary phase. Prior to that time, the disease was considered to be uniformly fatal and treatment was being given essen tially for palliation. These concepts have changed and now the well-informed investigator is employing acute leukemia protocols ...
Joseph H. Burchenal +2 more
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