Results 281 to 290 of about 401,465 (309)
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Hematology/Oncology Clinics of North America, 2009
Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms ...
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Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms ...
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Childhood acute lymphoblastic leukemia
Reviews in Clinical and Experimental Hematology, 2002As cure rates in childhood acute lymphoblastic leukemia reach 80%, emphasis is increasingly placed on the accurate identification of drug‐resistant cases, the elucidation of the mechanisms involved in drug resistance and the development of new therapeutic strategies targeted toward the pivotal molecular lesions.
Mary V. Relling +3 more
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Acute lymphoblastic leukemia in the elderly
European Journal of Haematology, 1990We report our findings in 18 patients with acute lymphoblastic leukemia (ALL) aged 60 years or older. A preleukemic syndrome was observed in 2 patients. Compared to younger adults with ALL, L3 morphology was unexpectedly frequent (4/16) T‐ALL was not observed. Other criteria of poor prognosis (high white blood cell count, CNS involvement, organomegaly,
Delannoy, André +7 more
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Childhood Acute Lymphoblastic Leukemia
Pediatric Annals, 1988Acute lymphoblastic leukemia accounts for 80% of leukemia in children. The exact cause is unknown, but some genetic, immunologic, viral, and environmental factors have been implicated. Symptoms at the time of diagnosis frequently include fever, bleeding, fatigue, and irritability. Initial white blood cell count and patient age at diagnosis are the most
Carol Diamond, Katherine K Matthay
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Asparaginase in Acute Lymphoblastic Leukemia
Clinical Lymphoma Myeloma and Leukemia, 2014Cure rates in pediatric acute lymphoblastic leukemia have significantly improved over the past decades. Now, almost 90% of children will survive the disease. The cure rates in adolescents, young adults, and adults have not kept pace with the improvements in younger patients, even though almost an equal proportion of adult patients achieve complete ...
Michael Rytting, Jitesh D. Kawedia
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Pharmacogenomics in acute lymphoblastic leukemia
Best Practice & Research Clinical Haematology, 2017Pharmacogenomics is a fast-growing field of personalized medicine using a patient's genomic profile to determine drug disposition or response to drug therapy, in order to develop safer and more effective pharmacotherapy. Childhood acute lymphoblastic leukemia (ALL), being the most common malignancy in childhood, which is treated with uniform and ...
Shawn H.R. Lee, Jun J. Yang
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Neonatal Acute Lymphoblastic Leukemia
Pediatric Emergency Care, 2020Abstract Acute lymphoblastic leukemia (ALL) in a neonate can have a similar clinical appearance to other serious pathology and should be considered in the ill-appearing infant. We present the case of a 24-hour-old male infant born to a mother with limited prenatal care who was brought to the pediatric emergency department with a rash and ...
Andrew L. Juergens +4 more
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Preleukemia in Acute Lymphoblastic Leukemia
Acta Haematologica, 1981A patient who presented with preleukemia evolving into acute lymphoblastic leukemia is described. The preleukemic phase was characterized by a positive acidified serum lysis test (Ham test).
I. Ariel +2 more
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Pharmacogenetics of acute lymphoblastic leukemia
Current Opinion in Hematology, 2004The outcome in children with acute lymphoblastic leukemia has improved significantly over the past four decades. Current therapy results in event-free survival exceeding 80% for most patients. The development of risk-adapted therapy based on characteristics of the child (age), leukemia (leukocyte count, acquired genetic characteristics) and early ...
Stella M. Davies, Parinda A. Mehta
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Mitoxantrone in acute lymphoblastic leukemia
Cancer Treatment Reviews, 1983Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethylamino]]9,10 anthracenedione dihydrochloride, CL 232,215 (NSC 301739) is a synthetic aminoanthraquinone which binds to DNA (2, 17), and was designed to reduce or eliminate the cardiotoxicity seen with the structurally related anthracycline antibiotics (1).
Takao Ohnuma +4 more
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