Results 191 to 200 of about 1,703,142 (259)

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source

SLV‐404, an anti‐RYK antibody–drug conjugate, is effective in Richter transformation patient‐derived xenografts

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract Richter transformation (RT), a highly aggressive lymphoma arising from a preexisting chronic lymphocytic leukemia, represents a major unmet clinical need. Recent data have shown that an antibody–drug conjugate (ADC) targeting the cell‐surface pseudokinase ROR1 is effective in RT patients.
Matilde Micillo, Beatrice Pirajno, Francesco Edoardo Vallone, Victor Navarro‐Tableros, Elisabetta Bolli, Valentina Griggio, Brian J. Lannutti, Katti A. Jessen, Tiziana Vaisitti, Silvia Deaglio   +9 more
wiley   +1 more source

A Retrospective Review of 1821 Cases of Eosinophilia in a Single‐Center Study in Eastern China

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Objective: Our study aims to explore the types of diseases that may cause eosinophilia and the changes in the disease spectrum of different degrees of eosinophilia. Methods We retrospectively analyzed patients who were admitted to the First Affiliated Hospital of Soochow University from July 1, 2023 to June 30, 2024, and had at least twice ...
Yanan Ma, Linlin Wang, Yuexin Cheng, Xiaofei Yang, Suning Chen   +4 more
wiley   +1 more source

Somatic Mitochondrial–Nuclear DNA Transfer in Lymphoproliferative Disorders

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Somatic mitochondrial–nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours. Methods EuroClonality‐NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for ...
James Peter Stewart, Nikos Darzentas, Miguel Alcoceba, Maria Eugenia Sarasquete, Anthony V. Moorman, Mark Catherwood, Binaya Regmi, Christiane Pott, Anton W. Langerak, David Gonzalez   +9 more
wiley   +1 more source

B-1 progenitor acute lymphoid leukemia.

Blood, 2019
Yoshimoto M.
europepmc   +1 more source

Repeated Response to Daratumumab in Refractory MGUS‐Associated Pure Red Cell Aplasia Persisting After Allogeneic Transplantation: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Pure red cell aplasia (PRCA) is usually managed as a disorder driven predominantly by cellular immune mechanisms, but plasma cell‐directed therapy may be relevant in selected cases associated with monoclonal gammopathy. We report a case of refractory PRCA associated with IgG‐kappa monoclonal gammopathy of undetermined significance (MGUS). A 64‐
Kyoko Yoshihara, Toshimitsu Matsui, Ikuo Matsuda, Mami Samori, Yoshiyuki Fujita, Saki Takahashi, Fuyuki Yamagata, Nobuto Utsunomiya, Chisato Ohe, Satoshi Yoshihara   +9 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source