Results 241 to 250 of about 361,051 (341)

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Vascular complications in NPM1-Mutated acute myeloid leukemia: clinical features and prognosis. [PDF]

Ann Hematol
Wang X, Mo W, Chen M, Sui J, Bian R, Yan X.   +5 more
europepmc   +1 more source

The Global Burden of Leukemia, 1990–2021: A Systematic Analysis of Prevalence, DALYs, and Risk Factors From the Global Burden of Disease Study

Med Research, EarlyView.
Using data from the Global Burden of Disease Study 2021, we systematically assessed leukemia prevalence and disability‐adjusted life years (DALYs) across 204 countries and territories from 1990 to 2021, stratified by subtype, demographics, and risk factors.
Yuping Wu, Haini Zhang, Shuang Luo, Xiangmei Zhang, Mei Tan, Jinmei Chen, Pei Huang, Yan Chen, Zuochen Du   +8 more
wiley   +1 more source

Association of the ABCB1 gene polymorphism C3435T (rs1045642) with acute myeloid leukemia: A genetic study. [PDF]

Hematol Transfus Cell Ther
Ullah R, Mazari N, Mustafa G, Hameed A, Khaliq S, Amar A, Haq FU, Khan AH, Naveed A.   +8 more
europepmc   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia. [PDF]

Cancer Res Commun
Guillen Magaña JN, Zannikou M, Baran A, Small S, Schieber M, Schipma MJ, Bartom ET, Kocherginsky M, Saleiro D, Beauchamp EM, Eckerdt F, Platanias LC.   +11 more
europepmc   +1 more source

Acute Myeloid Leukemia (AML): The Role of Intensive Induction Chemotherapy

, 2004
Thomas Büchner, W. Hiddemann, Wolfgang E. Berdel, Bernhard Wörmann, Helmut Löffler, Claudia Schoch, T. Haferlach, Wolfgang Ludwig, Georg Maschmeyer, Eva Lengelder, Peter Staib, Reinhard Andreesen, Leopold Balleisen, Detlef Haase, Hartmut Eimermacher, Andrea Schumacher, Carlo Aul, H. Rasche, Jens Uhlig, Andreas Grüneisen, H. E. Reis, J. Hartlapp, Wolf‐Dietrich Hirschmann, Hans-Josef Weh, Hermann-Josef Pielken, W. Gaßmann, Maria‐Cristina Sauerland, Achim Heinecke   +27 more
openalex   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

TIM-3 Promotes Proliferation of Acute Myeloid Leukemia Blasts. [PDF]

Biomedicines
Shi ZY, Sun K, Li ZY, Xie DH, Qin YZ.
europepmc   +1 more source