Results 71 to 80 of about 356,633 (356)

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Hierarchy in Gene Expression is Predictive for Adult Acute Myeloid Leukemia

, 2015
Cancer progresses with a change in the structure of the gene network in normal cells. We define a measure of organizational hierarchy in gene networks of affected cells in adult acute myeloid leukemia (AML) patients.
Deem, Michael W., Tripathi, Shubham
core   +1 more source

Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis [PDF]

, 2010
Background A substantial number of epidemiologic studies have provided estimates of the relation between exposure to benzene at work and the risk of leukemia, but the results have been heterogeneous.
A Le Noir, Abdul Khalade, AC Capleton, AR Schnatter, AR Schnatter, AS Costantini, AS Costantini, B Ireland, B Jarvholm, D Consonni, DA Savitz, DB Petitti, DB Richardson, DC Glass, Eero Pukkala, J Kirkeleit, JJ Collins, Jouni JK Jaakkola, L Rushton, LJ Bloemen, M Borenstein, Maritta S Jaakkola, RA Rinsky, RB Hayes, SH Lamm, T Sorahan, T Sorahan   +26 more
core   +4 more sources

Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223

Haematologica, 2010
Background Until recently, few molecular aberrations were recognized in acute lymphoblastic leukemia of T-cell origin; novel lesions have recently been identified and a certain degree of overlap between acute myeloid leukemia and T-cell acute ...
Sabina Chiaretti, Monica Messina, Simona Tavolaro, Giuseppe Zardo, Loredana Elia, Antonella Vitale, Alessandro Fatica, Paolo Gorello, Alfonso Piciocchi, Gina Scappucci, Irene Bozzoni, Claudio Fozza, Anna Candoni, Anna Guarini, Robin Foà   +14 more
doaj   +1 more source

Increased PRAME-specific CTL killing of acute myeloid leukemia cells by either a novel histone deacetylase inhibitor chidamide alone or combined treatment with decitabine. [PDF]

PLoS ONE, 2013
As one of the best known cancer testis antigens, PRAME is overexpressed exclusively in germ line tissues such as the testis as well as in a variety of solid and hematological malignant cells including acute myeloid leukemia.
Yushi Yao, Jihao Zhou, Lixin Wang, Xiaoning Gao, Qiaoyang Ning, Mengmeng Jiang, Jia Wang, Lili Wang, Li Yu   +8 more
doaj   +1 more source

AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arrest in Chronic and Acute Myeloid Leukemia Cells [PDF]

, 2023
Beatriz Lapa, Maria Inês Costa, Diana Figueiredo, Joana Jorge, Raquel Alves, Ana Raquel Monteiro, Beatriz Serambeque, Mafalda Laranjo, Maria Filomena Botelho, Isabel M. Carreira, Ana Bela Sarmento‐Ribeiro, Ana Cristina Gonçalves   +11 more
openalex   +1 more source

Therapy of Acute Myeloid Leukemia

Cancer Control, 2001
The Eastern Cooperative Oncology Group (ECOG) has recently reviewed the outcome for more than 1,400 patients with previously untreated AML entered on five successive clinical trials.5,6 Each trial included daunorubicin and cytarabine for induction.
openaire   +2 more sources

CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3

Advanced Science, EarlyView.
This study reveals that circPVT1 promotes the renal cell carcinoma lung metastasis and tumor progression through encoding the cP104aa peptide and directly binds with EIF4A3, which jointly regulates the target gene c‐MYC. Abstract Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC).
Houliang Zhang, Tao Tao, Jie Ji, Tonglei Zhao, Si Sun, Lijie Zhang, Jianping Wu, Ming Chen, Shuqiu Chen, Bin Xu, Weipu Mao   +10 more
wiley   +1 more source

Acute myeloid leukemia with fusion resembling acute promyelocytic leukemia, initially presenting as sweet syndrome: A case report and literature review

Journal of International Medical Research
Some subtypes of acute myeloid leukemia share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia but lack a promyelocytic leukemia–retinoic acid receptor alpha fusion gene.
Huan Liu, Guo-Xia Liu, Feng-Hai Liu, Shu-Guo Wang   +3 more
doaj   +1 more source

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

Haematologica, 2009
We examined the gene expression profiles of two independent cohorts of patients with acute myeloid leukemia [n=247 and n=214 (younger than or equal to 60 years)] to study the applicability of gene expression profiling as a single assay in prediction of ...
Roel G.W. Verhaak, Bas J. Wouters, Claudia A.J. Erpelinck, Saman Abbas, H. Berna Beverloo, Sanne Lugthart, Bob Löwenberg, Ruud Delwel, Peter J.M. Valk   +8 more
doaj   +1 more source