Targeting self-renewal pathways in myeloid malignancies [PDF]
, 2013 A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core +2 more sources
Definitions, 2020 Acute Myeloid Leukemia (AML) is a type of clonal hematological malignancies originating from hematopoietic stem cells. At present, the diagnosis and classification, treatment selection and prognosis assessment of AML patients have entered the era of ...
Xiaoxiao Lu, Fang Zhao
semanticscholar +1 more source
Questions and answers about leukemia [PDF]
Leukemia is cancer of the white blood cells. It develops in the bone marrow and spreads into the blood and to other organs. There are several types of leukemia. They are grouped in two ways: by how rapidly the disease develops (acute vs. chronic leukemia)
core
Hierarchy in Gene Expression is Predictive for Adult Acute Myeloid Leukemia
, 2015 Cancer progresses with a change in the structure of the gene network in normal cells. We define a measure of organizational hierarchy in gene networks of affected cells in adult acute myeloid leukemia (AML) patients.
Deem, Michael W., Tripathi, Shubham
core +1 more source
A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling [PDF]
, 2018 Trib2 pseudokinase is involved in the etiology of a number of cancers including leukaemia, melanoma, ovarian, lung and liver cancer. Both high and low Trib2 expression levels correlate with different types of cancer.
Carmody, Ruaidhri J. +6 more
core +2 more sources
Overexpression of the protein kinase CK2 increases the survival and resistance to chemotherapy of acute myeloid leukemia cells [PDF]
, 2013 Background: The critical role of protein kinase CK2 in the regulation of cellular apoptosis suggests its may be involvement in tumor cell resistance to both conventional and unconventional therapies.
PAVAN, LAURA
core +1 more source
The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA [PDF]
, 2016 Alterations in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells.
Bozzoni, Irene +8 more
core +2 more sources
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors [PDF]
, 2002 FLT3 mutations, either internal tandem duplications (ITDs) or aspartate residue 835 (D835) point mutations, are present in approximately one third of patients with acute myeloid leukemia (AML) and have been associated with an increased relapse rate.
Bowen, D.T. +5 more
core +1 more source
Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]
, 2019 The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I +20 more
core +1 more source
Global Stability Analysis of Healthy Situation for a Coupled Model of Healthy and Cancerous Cells Dynamics in Acute Myeloid Leukemia [PDF]
, 2017 In this paper we aim to study the global stability of a coupled model of healthy and cancerous cells dynamics in healthy situation of Acute Myeloid Leukemia.
Chakir, M., Tadjine, M., Zenati, A.
core +1 more source