Results 61 to 70 of about 1,534,143 (162)

Real‐World Evidence for Existing Anti‐Obesity Therapies—The Realities of Treatment Adherence, Tolerability, Access and Patient Satisfaction

Diabetes, Obesity and Metabolism, Volume 28, Issue S5, Page 3-26, September 2026.
ABSTRACT Background Obesity is associated with substantial cardiometabolic and psychosocial morbidity. Although randomized controlled trials demonstrate the efficacy of anti‐obesity therapies, outcomes in real‐world practice may be attenuated due to limited access, tolerability, adherence and insufficient long‐term support.
Sameer Kassem
wiley   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Acute oxalate nephropathy due to ′Averrhoa bilimbi′ fruit juice ingestion

Indian Journal of Nephrology, 2013
Irumban puli (Averrhoa bilimbi) is commonly used as a traditional remedy in the state of Kerala. Freshly made concentrated juice has a very high oxalic acid content and consumption carries a high risk of developing acute renal failure (ARF) by deposition of calcium oxalate crystals in renal tubules.
Bakul, G., Unni, V. N., Seethaleksmy, N. V., Mathew, A., Rajesh, R., Kurien, G., Rajesh, J., Jayaraj, P. M., Kishore, D. S., Jose, P. P.   +9 more
openaire   +2 more sources

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, Volume 13, Issue 46, 17 August 2026.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Current therapeutic management of diabetic nephropathy [PDF]

, 1994
Roughly 40% of all patients with insulin-dependent diabetes mellitus (IDDM) develop diabetic nephropathy with proteinuria, hypertension and a decrease in glomerular filtration rate 10 to 20 years after the onset of the disease, and 5 years later most ...
Kohler, S. M., Krämer, Bernhard K.
core   +1 more source

Dysmetabolic nephropathy as a risk factor of pylonephritis in children

Zdorovʹe Rebenka, 2018
Background. Dysmetabolic nephropathies contribute to the development of urinary stone disease in children, the emergence of an infection of the urinary system, secondary pyelonephritis and formation of tubulo-interstitial changes in the kidneys. The main
L.I. Vakulenko
doaj   +1 more source

Kidney Stone, Nutritional Perceptions and Impact of Tea on Stone Formation

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
ABSTRACT The significant financial burden that urinary stone disease places on healthcare systems is only anticipated to increase over time. It is becoming more common over the globe. It is an increasing urinary condition that impacts around 12% of the global population, and environmental variables appear to be a key contributor.
Munir Ahmed, Danish Kamal, Umber Mubeen, Sakhawat Riaz, Amber Tehseen, Muhammad Mazahir   +5 more
wiley   +1 more source