Results 151 to 160 of about 1,088,698 (343)

Effect of an Ultra-Diluted Complex on Health, Growth Performance, and Blood Parameters of Pre-Weaned Dairy Calves

open access: yesVeterinary Sciences
This study aimed to evaluate the effects of an ultra-diluted complex on the health status, growth performance, and blood parameters of dairy calves during the preweaning phase in a double-blind, placebo-controlled trial.
Mellory M. Martins   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Effects of postbiotic products from Saccharomyces cerevisiae fermentation on lactation performance, antioxidant capacity, and blood immunity in transition dairy cows

open access: yesJournal of Dairy Science
: This study aimed to evaluate the effects of dietary supplementation with different types of Saccharomyces cerevisiae fermentation products (SCFP) on lactational performance, metabolism, acute phase protein response, and antioxidant capacity in dairy ...
Dongwen Dai   +10 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Editorial: The Role of Pentraxins: From Inflammation, Tissue Repair and Immunity to Biomarkers

open access: yesFrontiers in Immunology, 2019
Barbara Bottazzi   +3 more
doaj   +1 more source

The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of Aβ burden through induction of APP amyloidogenic processing. [PDF]

open access: yesMol Psychiatry, 2021
Tsatsanis A   +10 more
europepmc   +1 more source

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