SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Levels of acute phase proteins remain stable after ischemic stroke [PDF]
, 2006 Mitchell S.V. Elkind +5 more
openalex +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Sportomics Analyses of the Exercise-Induced Impact on Amino Acid Metabolism and Acute-Phase Protein Kinetics in Female Olympic Athletes. [PDF]
NutrientsMuniz-Santos R +7 more
europepmc +1 more source
Acute Phase Response with Special Reference to C-Reactive Protein in Dogs with Generalized Demodicosis [PDF]
, 2011 Bülent Ulutaş +2 more
openalex
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Comparative Analysis of Acute-Phase Protein Profiles in Cats Undergoing Ovariectomy: Laparoscopic vs. Conventional Surgery in Short Time After Procedure. [PDF]
Animals (Basel)Cuervo B +10 more
europepmc +1 more source
Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve. [PDF]
Curr Atheroscler Rep, 2020 Gursky O.
europepmc +1 more source
Relationship between angiotensinogen, alpha-1-protease inhibitor elastase complex, antithrombin III and C-reactive protein in septic ARDS [PDF]
, 1990 Hilgenfeldt, U. +3 more
core +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source