Results 21 to 30 of about 437,026 (309)

A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

EMBO Molecular Medicine, 2015
The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetramer and releasing
Julien Marcoux, P Patrizia Mangione, Riccardo Porcari, Matteo T Degiacomi, Guglielmo Verona, Graham W Taylor, Sofia Giorgetti, Sara Raimondi, Sarah Sanglier‐Cianférani, Justin LP Benesch, Ciro Cecconi, Mohsin M Naqvi, Julian D Gillmore, Philip N Hawkins, Monica Stoppini, Carol V Robinson, Mark B Pepys, Vittorio Bellotti   +17 more
doaj   +1 more source

Acute Phase Proteins and Their Role in Periodontitis: A Review [PDF]

Journal of Clinical and Diagnostic Research, 2015
Acute phase proteins are a class of proteins whose plasma concentration increase (positive acute phase proteins) or decrease (negative acute phase proteins) in response to inflammation. This response is called as the acute phase reaction, also called as
Tejaswin Polepalle, Srinivas Moogala, Shalini Boggarapu, Divya Sai Pesala, Firoz Babu Palagi   +4 more
doaj   +1 more source

The Pentraxins 1975–2018: Serendipity, Diagnostics and Drugs

Frontiers in Immunology, 2018
The phylogenetically ancient, pentraxin family of plasma proteins, comprises C-reactive protein (CRP) and serum amyloid P component (SAP) in humans and the homologous proteins in other species.
Mark. B. Pepys, Mark. B. Pepys
doaj   +1 more source

Effect of short-term abomasal corn starch infusions on postruminal fermentation and blood measures

Journal of Dairy Science, 2023
: It is possible that some of the systemic responses to subacute ruminal acidosis (SARA) may be caused by increased intestinal starch fermentation. The objective of this experiment was to evaluate the effect of abomasal infusion of up to 3 g of corn ...
S.K. Cronin, A.M. Barnard, S.J. Dietz, M. Lawrence, A.E. Kramer, T.F. Gressley   +5 more
doaj   +1 more source

Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

Cell Reports, 2015
Multinucleated giant cells (MGCs) form by fusion of macrophages and are presumed to contribute to the removal of debris from tissues. In a systematic in vitro analysis, we show that IL-4-induced MGCs phagocytosed large and complement-opsonized materials ...
Ronny Milde, Julia Ritter, Glenys A. Tennent, Andrzej Loesch, Fernando O. Martinez, Siamon Gordon, Mark B. Pepys, Admar Verschoor, Laura Helming   +8 more
doaj   +1 more source

A Narrative Review of the Role of Transthyretin in Health and Disease

Neurology and Therapy, 2020
Transthyretin (TTR) is a tetrameric transport protein highly conserved through vertebrate evolution and synthesized in the liver, choroid plexus, and retinal pigment epithelium. TTR transports the thyroid hormone thyroxine and the retinol-binding protein
Marcia Almeida Liz, Teresa Coelho, Vittorio Bellotti, Maria Isabel Fernandez-Arias, Pablo Mallaina, Laura Obici   +5 more
doaj   +1 more source

The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis

The Journal of Pathology: Clinical Research, 2019
The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial for clinical management, have traditionally relied on Congo red (CR) staining followed by immunohistochemistry (IHC) using fibril protein specific antibodies ...
Tamer Rezk, Janet A Gilbertson, P Patrizia Mangione, Dorota Rowczenio, Nigel B Rendell, Diana Canetti, Helen J Lachmann, Ashutosh D Wechalekar, Paul Bass, Philip N Hawkins, Vittorio Bellotti, Graham W Taylor, Julian D Gillmore   +12 more
doaj   +1 more source

Acute phase response in lame crossbred dairy cattle [PDF]

Veterinary World, 2016
Aim: The study was undertaken to study acute phase response based on acute phase proteins (APPs) such as C-reactive protein (CRP), haptoglobin (Hp), serum amyloid A (SAA), and fibrinogen in lame crossbred dairy cattle.
A. Bagga, Swaran Singh Randhawa, S. Sharma, B. K. Bansal   +3 more
doaj   +1 more source

Blood fibrinogen concentrations in New Zealand White rabbits during the first year of life [PDF]

Bulgarian Journal of Veterinary Medicine, 2018
The aim of this study was to examine the reference range of blood plasma fibrinogen, which belongs to the group of moderate acute phase protein in rabbits. The experiment followed the dynamics of blood plasma fibrinogen (Fb) during the first year of life
Y. Petrova, V. Petrov, T. M. Georgieva, F. Ceciliani   +3 more
doaj   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source