Results 21 to 30 of about 593,677 (304)
Analysis of Cardiac Amyloidosis Progression Using Model-Based Markers
Frontiers in Physiology, 2020 Deposition of amyloid in the heart can lead to cardiac dilation and impair its pumping ability. This ultimately leads to heart failure with worsening symptoms of breathlessness and fatigue due to the progressive loss of elasticity of the myocardium ...
Wenguang Li +11 more
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Clinical profile and treatment outcome of older (>75 years) patients with systemic AL amyloidosis
Haematologica, 2015 Systemic AL amyloidosis, a disease with improving outcomes using novel therapies, is increasingly recognized in the elderly but treatment and outcomes have not been systematically studied in this group of patients in whom comorbidities and frailty may ...
Sajitha Sachchithanantham +10 more
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Scientific Reports, 2021 Hereditary transthyretin-mediated (hATTR) amyloidosis is an underdiagnosed, progressively debilitating disease caused by mutations in the transthyretin (TTR) gene.
Margaret M. Parker +21 more
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C. elegans feed yolk to their young in a form of primitive lactation
Nature Communications, 2021 It is unclear why C. elegans continues to produce large quantities of yolk after reproduction. Here the authors show that post-reproductive C. elegans mothers vent yolk which supports their offspring’s growth, serving as a form of primitive lactation.
Carina C. Kern +8 more
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Acute-phase protein synthesis: a key feature of innate immune functions of the liver
Biological chemistry, 2021 The expression of acute-phase proteins (APP’s) maintains homeostasis and tissue repair, but also represents a central component of the organism’s defense strategy, especially in the context of innate immunity.
C. Ehlting, S. Wolf, J. Bode
semanticscholar +1 more source
The importance of acute-phase proteins as markers in cancers
Studia Medyczne, 2021 Acute-phase proteins (APPs) form a group of heterogeneous proteins whose synthesis takes place in the liver. This involves mediators such as cytokines and constitutes a response to acute inflammations, bacterial infections, tumours, and autoimmune ...
Paulina Zegarska +2 more
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Acute-phase proteins during inflammatory reaction by bacterial infection: Fish-model
Scientific Reports, 2019 Acute-phase protein (APPs) serum levels have been studied in many human diseases, and their components contribute to host defense during the evolution of infectious diseases by acting as part of the innate immune system.
I. Charlie-Silva +13 more
semanticscholar +1 more source
Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein
Kidney International Reports, 2017 Fibrinogen A alpha chain amyloidosis is an autosomal dominant disease associated with mutations in the fibrinogen A alpha chain (FGA) gene, and it is the most common cause of hereditary renal amyloidosis in the UK.
Dorota Rowczenio +18 more
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Acute phase proteins in sheep and goats – function, reference ranges and assessment methods: An overview [PDF]
Bulgarian Journal of Veterinary Medicine, 2018 Acute phase response (APR) is activated by disorders in systemic homeostasis. The main purpose of APR is to prevent further tissue damage by isolation and destruction of causative agent, removing the toxic products and providing conditions for tissue ...
P. Iliev, T. Mircheva-Georgieva
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Scientific Reports, 2017 Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds ...
Guglielmo Verona +11 more
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