Results 31 to 40 of about 7,955,704 (317)

Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis

Kidney International Reports, 2019
Introduction: Hereditary fibrinogen Aα-chain (AFib) amyloidosis is a relatively uncommon renal disease associated with a small number of pathogenic fibrinogen Aα (FibA) variants; wild-type FibA normally does not result in amyloid deposition.
Graham W. Taylor, Janet A. Gilbertson, Rabya Sayed, Angel Blanco, Nigel B. Rendell, Dorota Rowczenio, Tamer Rezk, P. Patrizia Mangione, Diana Canetti, Paul Bass, Philip N. Hawkins, Julian D. Gillmore   +11 more
doaj   +1 more source

Acute-phase proteins during inflammatory reaction by bacterial infection: Fish-model

Scientific Reports, 2019
Acute-phase protein (APPs) serum levels have been studied in many human diseases, and their components contribute to host defense during the evolution of infectious diseases by acting as part of the innate immune system.
I. Charlie-Silva, A. Klein, J. M. M. Gomes, E. Prado, A. C. Moraes, S. F. Eto, D. C. Fernandes, J. Fagliari, J. D. Corrêa, C. Lima, M. Lopes-Ferreira, Katia Conceição, W. Manrique, M. A. Belo   +13 more
semanticscholar   +1 more source

Acute-phase protein synthesis: a key feature of innate immune functions of the liver

Biological chemistry, 2021
The expression of acute-phase proteins (APP’s) maintains homeostasis and tissue repair, but also represents a central component of the organism’s defense strategy, especially in the context of innate immunity.
C. Ehlting, S. Wolf, J. Bode
semanticscholar   +1 more source

Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A [PDF]

, 2010
Elevated levels of acute-phase serum amyloid A (A-SAA) cause amyloidosis and are a risk factor for atherosclerosis and its clinical complications, type 2 diabetes, as well as various malignancies.
Illig, T, Spector Tim D., Kleber, M.E., März Winfried, Wichmann, H. -Erich, Mangino, M, Waldenberger, M, Hammond Christopher J., Prokopenko, I, Hammond, Christopher J., Blackburn Hannah, Prokisch Holger, Winkelmann Bernhard R., Mangino, M., H.-Erich Wichmann, Kovacs, P., Wichmann, H.-E., Marzi, C, Illig, T., Waldenberger, Melanie, Tim D Spector, Geistlinger, Ludwig, Tönjes, A, Koenig Wolfgang, Peters, Annette, Thorand, Barbara, Illig Thomas, Boehm, Bernhard O., Toenjes, Anke, Peters Annette, Boehm Bernhard O., Hysi, P.G., Kovacs, Peter, Prokisch, H., Mangino Massimo, Marcus E Kleber, Annette Peters, Prokopenko, I., Pirro G. Hysi, Soranzo, Nicole, Christopher J. Hammond, Hysi, Pirro G., Koenig, W, Tönjes Anke, Hammond, C.J., Heim, K., Harald Grallert, H-Erich Wichmann, Bernhard O. Boehm, Marzi, C., Koenig, W., Gieger, Christian, Eva Albrecht, Soranzo, N, Hammond, CJ, Albrecht Eva, Hysi Pirro G., Vasiliki Lagou, Grallert, H., Koenig, Wolfgang, Nicole Soranzo, Spector, Tim D., Gieger, C, Marz, W., Melanie Waldenberger, Michael Stumvoll, Thorand Barbara, Hysi, PG, Boehm, BO, Carola Marzi, Boehm, B.O., Janina S Ried, Lagou, Vasiliki, Wichmann, Heinz-Erich, Bernhard R. Winkelmann, Inga Prokopenko, Hannah Blackburn, Heim, Katharina, Kleber, ME, Peters, A, Stumvoll, M, Anke Tönjes, März, W, Gieger, C., Ried, Janina S., Christian Gieger, Ried, JS, Bernhard O Boehm, Albrecht, E, Blackburn, H, Stumvoll, M., Pirro G Hysi, Lagou Vasiliki, Ried Janina S., Waldenberger Melanie, Thorand, B, Christopher J Hammond, Lagou, V, Gieger Christian, Blackburn, Hannah, Grallert, Harald, Heim, K, Kleber Marcus E., Prokopenko Inga, Spector, T.D., Marzi, Carola, Waldenberger, M., Winkelmann, B.R., Heim Katharina, Wichmann H.-Erich, Kleber, Marcus E., Wolfgang Koenig, Barbara Thorand, Tönjes, A., Soranzo, N., Winfried März, Prokisch, Holger, Stumvoll, Michael, Marcus E. Kleber, Tim D. Spector, Mangino, Massimo, Stumvoll Michael, Grallert, H, Wichmann, HE, Geistlinger, L, Peters, A., Illig, Thomas, Maerz, Winfried, Ried, J.S., Grallert Harald, Thomas Illig, Albrecht, Eva, Lagou, V., Bernhard R Winkelmann, Kovacs Peter, Geistlinger Ludwig, Kovacs, P, Prokisch, H, Prokopenko, Inga, Katharina Heim, Marzi Carola, Soranzo Nicole, Massimo Mangino, Ludwig Geistlinger, Geistlinger, L., Blackburn, H., Peter Kovacs, Spector, TD, Janina S. Ried, Albrecht, E., Thorand, B., Winkelmann, BR, Winkelmann, Bernhard R., Holger Prokisch, Marzi, C;Albrecht, E;Hysi, PG;Lagou, V;Waldenberger, M;Tönjes, A;Prokopenko, I;Heim, K;Blackburn, H;Ried, JS;Kleber, ME;Mangino, M;Thorand, B;Peters, A;Hammond, CJ;Grallert, H;Boehm, BO;Kovacs, P;Geistlinger, L;Prokisch, H;Winkelmann, BR;Spector, TD;Wichmann, HE;Stumvoll, M;Soranzo, N;März, W;Koenig, W;Illig, T;Gieger, C   +154 more
core   +2 more sources

Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein

Kidney International Reports, 2017
Fibrinogen A alpha chain amyloidosis is an autosomal dominant disease associated with mutations in the fibrinogen A alpha chain (FGA) gene, and it is the most common cause of hereditary renal amyloidosis in the UK.
Dorota Rowczenio, Maria Stensland, Gustavo A. de Souza, Erik H. Strøm, Janet A. Gilbertson, Graham Taylor, Nigel Rendell, Shane Minogue, Yvonne A. Efebera, Helen J. Lachmann, Ashutosh D. Wechalekar, Philip N. Hawkins, Ketil R. Heimdal, Kristian Selvig, Inger K. Lægreid, Nathalie Demoulin, Selda Aydin, Julian D. Gillmore, Tale N. Wien   +18 more
doaj   +1 more source

The importance of acute-phase proteins as markers in cancers

Studia Medyczne, 2021
Acute-phase proteins (APPs) form a group of heterogeneous proteins whose synthesis takes place in the liver. This involves mediators such as cytokines and constitutes a response to acute inflammations, bacterial infections, tumours, and autoimmune ...
Paulina Zegarska, Urszula Markowska, Małgorzata Płoszaj   +2 more
doaj   +1 more source

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel

Scientific Reports, 2017
Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds ...
Guglielmo Verona, P. Patrizia Mangione, Sara Raimondi, Sofia Giorgetti, Giulia Faravelli, Riccardo Porcari, Alessandra Corazza, Julian D. Gillmore, Philip N. Hawkins, Mark B. Pepys, Graham W. Taylor, Vittorio Bellotti   +11 more
doaj   +1 more source

Acute phase proteins in sheep and goats – function, reference ranges and assessment methods: An overview [PDF]

Bulgarian Journal of Veterinary Medicine, 2018
Acute phase response (APR) is activated by disorders in systemic homeostasis. The main purpose of APR is to prevent further tissue damage by isolation and destruction of causative agent, removing the toxic products and providing conditions for tissue ...
P. Iliev, T. Mircheva-Georgieva
doaj   +1 more source

Efficacy of bortezomib, cyclophosphamide and dexamethasone in treatment-naïve patients with high-risk cardiac AL amyloidosis (Mayo Clinic stage III)

Haematologica, 2014
Bortezomib is an active agent in AL amyloidosis and responses to this drug in combination with cyclophosphamide and dexamethasone are both rapid and deep.
Arnaud Jaccard, Raymond L. Comenzo, Parameswaran Hari, Philip N. Hawkins, Murielle Roussel, Pierre Morel, Margaret Macro, Jean-Luc Pellegrin, Estibaliz Lazaro, Dania Mohty, Patrick Mercie, Olivier Decaux, Julian Gillmore, David Lavergne, Frank Bridoux, Ashutosh D. Wechalekar, Christopher P. Venner   +16 more
doaj   +1 more source

Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics

Molecular Biosystems, 2016
Acute phase proteins and a group of 77 peptides in a biomarker panel increase in milk during bovine mastitis caused by a Streptococcus uberis infection of mammary glands.
F. Thomas, W. Mullen, R. Tassi, Adela Ramírez-Torres, Manikhandan Mudaliar, T. McNeilly, R. Zadoks, R. Burchmore, P. Eckersall   +8 more
semanticscholar   +1 more source